Mutation status | No of relatives | All cancers | Breast or ovary cancer | Other cancers | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Obs | SIR | Obs | SIR | Obs | SIR | ||||||||
All categories | |||||||||||||
Mothers | 97 | 35 | 1.4 | 20 | 2.94-150 | 15 | 0.8 | ||||||
Fathers | 95 | 26 | 1.0 | 0 | 0.0 | 26 | 1.0 | ||||||
Sisters | 78 | 11 | 2.34-150 | 7 | 4.34-150 | 4 | 1.3 | ||||||
Brothers | 84 | 11 | 3.34-150 | 0 | 0.0 | 11 | 3.24-150 | ||||||
All relatives | 566 | 854-151 | 1.44-150 | 27 | 3.14-150 | 58 | 1.1 | ||||||
BRCA1 carriers | |||||||||||||
Mothers | 12 | 10 | 3.94-150 | 7 | 10.34-150 | 3 | 1.6 | ||||||
Fathers | 12 | 3 | 1.0 | 0 | 0.0 | 3 | 1.0 | ||||||
Sisters | 11 | 4 | 8.44-150 | 3 | 18.14-150 | 1 | 3.2 | ||||||
Brothers | 14 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||||||
All relatives | 75 | 17 | 2.54-150 | 10 | 11.64-150 | 7 | 1.2 | ||||||
BRCA2 carriers | |||||||||||||
Mothers | 10 | 3 | 1.4 | 3 | 4.94-150 | 0 | 0.0 | ||||||
Fathers | 10 | 2 | 0.8 | 0 | 0.0 | 2 | 0.8 | ||||||
Sisters | 8 | 1 | 3.1 | 1 | 9.7 | 0 | 0.0 | ||||||
Brothers | 5 | 1 | 4.7 | 0 | 0.0 | 1 | 4.7 | ||||||
All relatives | 51 | 7 | 1.3 | 4 | 5.54-150 | 3 | 0.7 | ||||||
Unknown variants | |||||||||||||
Mothers | 10 | 2 | 0.6 | 0 | 0.0 | 2 | 0.8 | ||||||
Fathers | 10 | 3 | 0.9 | 0 | 0.0 | 3 | 0.9 | ||||||
Sisters | 2 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||||||
Brothers | 9 | 3 | 9.54-150 | 0 | 0.0 | 3 | 9.54-150 | ||||||
All relatives | 60 | 8 | 1.1 | 0 | 0.0 | 8 | 1.2 | ||||||
Wild type genotype | |||||||||||||
Mothers | 65 | 20 | 1.1 | 10 | 2.14-150 | 10 | 0.8 | ||||||
Fathers | 63 | 18 | 1.1 | 0 | 0.0 | 18 | 1.1 | ||||||
Sisters | 57 | 6 | 1.6 | 3 | 2.3 | 3 | 1.2 | ||||||
Brothers | 56 | 7 | 3.04-150 | 0 | 0.0 | 7 | 3.04-150 | ||||||
All relatives | 380 | 534-151 | 1.3 | 13 | 2.14-150 | 40 | 1.1 |