Distribution of the GSTP1 105Ile→Val polymorphism in pre-eclampsia mother-father-baby trios
| PE mothers (n=113) | PE fathers (n=113) | PE offspring (n=111) | Controls (n=317) | |
|---|---|---|---|---|
| Percentages are given in parentheses. GSTP1 genotypes: Ile105/Ile105, wild type; Ile105/Val105, heterozygous; Val105/Val105, homozygous. PE, pre-eclampsia; OR (95% CI), odds ratio and 95% confidence interval calculated for the Val105/Val105 genotype versus the other two genotypes in pre-eclampsia mothers, fathers, and offspring versus Dutch population based controls. | ||||
| GSTP1 polymorphism could not be determined in two children. | ||||
| Genotype | ||||
| Ile105/Ile105 | 51 (45) | 47 (42) | 40 (36) | 187 (59) |
| Ile105/Val105 | 51 (45) | 49 (43) | 58 (52) | 120 (38) |
| Val105/Val105 | 11 (10) | 17 (15) | 13 (12) | 10 (3) |
| OR (95% CI) | 3.3 (1.3-8.7) | 5.4 (2.3-13.3) | 4.1 (1.6-10.4) | 1 |