Microsatellite markers in the vicinity of the GUCY2D gene
| Intermarker distance (cM) | Association with disease | Haplotypes or genotypes in families or probands | |||||||
|---|---|---|---|---|---|---|---|---|---|
| λ | p | 2 | 3 | 4 | 5 | 6 | |||
| D17S796 | 0 | 0.5 | 2 (0.25) | 5 (0.30) | 2 | 25 | 1 (0.23) | ||
| 0.13 | |||||||||
| D17S938 | 0.36 | 0.25 | 7 (0.06) | 1 (0.31) | 1 | 1,3 (0.03) | 7 | ||
| 0.2 | |||||||||
| D17S960 | 0.57 | 0.03 | 5 (0.28) | 5 | 3 (0.21) | 5 | 5 | ||
| 0 | |||||||||
| GUCY2D | — | — | R838C | R838C | R838C | R838C | R838C | ||
| 0 | |||||||||
| D17S1796 | 0 | 0.5 | 2 (0.60) | 4 (0.30) | 2 | 2,5 (0.10) | 2 | ||
| 0 | |||||||||
| D17S1881 | 0.53 | 0.07 | 6 (0.17), 8 (0.10) | 5 (0.34) | 5 | 5 | 5 | ||
| 2.2 | |||||||||
| D17S1852 | ND | 7 | 612 | 910 | 67 | 78 | |||
The family numbers are identical to those in table 1. The numbers in parentheses are the frequencies of each allele on 40 chromosomes obtained from unrelated, “married in” subjects in the families. The statistic λ gives an estimate of linkage disequilibrium as determined by the DISLAMB program.9 Only D17S960 shows significant disease association.