Diagnostic criteria for Li-Fraumeni syndrome and Li-Fraumeni-like syndrome
| Li-Fraumeni syndrome3 | Li-Fraumeni like syndrome17 |
|---|---|
| Proband <45 years with a sarcoma | Proband with any childhood tumour, or sarcoma, brain tumour, or adrenocortical tumour <45 years |
| Plus 1st degree relative <45 years with any cancer | Plus 1st or 2nd degree relative in the same lineage with typical LFS tumour at any age or any cancer <45 years |
| Plus additional 1st or 2nd degree relative in the same lineage aged <45 years with any cancer or a sarcoma at any age | Plus another 1st or 2nd degree relative in the same lineage with any cancer <60 years |