Clinical profile of the proband
| Time (minutes) | oGTT | TRH test | |||||
|---|---|---|---|---|---|---|---|
| Glucose (mg/dl) | Insulin (μIU/ml) | GH (ng/ml) | TSH (μIU/ml) | PRL (ng/ml) | GH (ng/ml) | ||
| 0 | 87 | 16.1 | 2.8 | 2.3 | 9.4 | 0.2 | |
| 15 | 12.8 | 62.3 | 0.6 | ||||
| 30 | 97 | 26.6 | 0.8 | 18.4 | 56.1 | 0.3 | |
| 45 | 15.6 | 46.8 | 0.2 | ||||
| 60 | 116 | 34.6 | 0.3 | 16 | 32.2 | 0.1 | |
| 90 | 109 | 34.9 | 0.3 | ||||
| 120 | 101 | 21.1 | 0.9 | ||||
| 180 | 94 | 21.9 | 0.1 | ||||
| Other tests | |||||||
| Peak GH to clonidine | 10.1 ng/ml | ||||||
| Peak GH to arginine | 15.6 ng/ml | ||||||
| IGF-1 | 429 ng/ml (age related normal range 286–660, mean 403) | ||||||
| IGFBP-3 | 3 mg/l (age related normal range 2.2–5.9, mean 4.2) | ||||||
| IGF-2 | 348 ng/ml (age related normal range 245–737, mean 491) | ||||||
| GHRH | 19 pg/ml (normal values are less than 50 pg/ml) | ||||||
| GHBP | 139 pmol/l (age related normal range 52–783 pmol/l) | ||||||
| C peptide | 1.2 ng/ml (normal fasting values 0.4–2.1 ng/ml) | ||||||