Table 1

(Pre)malignant tumours in the extended Dutch MSH6 family

Patient Tumour Age at diagnosis MSH6 mutation
II.2Colorectal cancer60Obligate carrier
III.2Transitional cell carcinoma right pyelum77Obligate carrier
& transitional cell carcinoma left ureter79
III.4Transitional cell carcinoma78+
III.6Unknown40Not tested
III.11Endometrial carcinoma?Obligate carrier
Colon carcinoma>70
III.13Colon carcinoma>70Not tested
III.18Colon carcinoma83+
III.19Astrocytoma75Not tested
IV.4Transitional cell carcinoma ureter59+
IV.6Multiple adenomatous polyps of the colon53−
IV.8Adenoma50+
IV.9Adenoma48+
IV.11Tubulovillous adenoma60+
IV.13Endometrial & rectal carcinoma55+
IV.14Breast cancer51Not tested
IV.15Breast & colon carcinoma49+
IV.20Breast cancer>50Not tested
IV.26Endometrial carcinoma57+
IV.27Endometrial carcinoma60+
IV.30Endometroid adenocarcinoma ovary50+
IV.32Endometrial carcinoma53+
IV.33Endometrial carcinoma50+
V.8Colorectal cancer32+

  • + indicates the presence of the MSH6mutation.

  • − indicates the absence of the MSH6 mutation.