Table 1

Haplotype data in families linked to the chromosome 2p16 dominant drusen locus. Italicised area indicates common haplotype and thus common ancestry. Bar indicates EFEMP1 intragenic markers

Pedigree		D2S2739		D2S2352		D2S2251		133018CA		EFEMP1		322A4AAT	D2S378
Pedigree		D2S2739		D2S2352		D2S2251		133018CA		Intron 4	Intron 8	322A4AAT	D2S378	Intron 9	R345W mutation
UK1	7	2	11	2	1	2	U	Yes	3	3
UK2	10	5	11	3	1	2	U	Yes	3	3
UK3	10	5	11	3	1	2	U	Yes	3	3
UK4	3	5	11	3	1	2	U	Yes	3	3
US1	5	4	11	3	U	2	2	Yes	3	3
US2	10	2	8	3	1	2	2	Yes	2	2
US3	6	2	10	3	1	2	2	Yes	3	2
UK5	7	2	8	3	U	2	2	No	3	9
UK6	6	7	6	1	U	2	2	No	2	8

U = uninformative. Families UK5 and UK6, despite linkage to the region, do not share the common haplotype or have theR345W mutation.