Table 1

Studies of psychological functioning of HD risk carriers

Study	Sample size	Carrier/ non-carrier/ uninformative^1-150	Mean age	Measurement time	Objective	Statistical methods
Boston
Meissen et al 14	15	4/7/5	—	Baseline, 3 mth, 9 mth		Percentages
Vancouver
Blochet al ⁴	51	NA	39.3	Before test	Description	Percentages
Wiggins et al 21 ^1-151	135	37/58/40	37.5	Baseline, 1 wk, 6 mth, 12 mth	Course	ANOVA, Kruskal-Wallis test
Lawsonet al 13 ^1-151	135	37/58/40	37.5	Baseline, 1 wk, 6 mth, 12 mth	Prediction, description	t tests or Mann-Whitney U tests, chi-square test
Baltimore
Folsteinet al 11	112	NA	26.7	NA	Description	Percentages, chi-square test
Brandt et al ⁵	55	12/30/13	35.4	Baseline, 3 mth, 6 mth, 9 mth, 12 mth	Description, baseline, course	Percentages
Folstein12	147/161	NA	—	NA	Description	Clinical impressions
Codori and Brandt⁶	68	17/51	37.7	8 visits in 3 y after test	Description	Percentages
Codori et al ⁷	160	52/108/—	34.4	Baseline, 3 mth, 6 mth, 9 mth, 12 mth	Prediction	F tests
Rotterdam/Leiden
Tibben et al 16	18	9/9	35.9	12 mth	Description	Percentages, clinical impressions
Tibbenet al 17 ^‡	63	29/44	31.6	Baseline, 6 mth	Prediction	Backward regression analysis
Tibbenet al 18 ^‡	63	24/39	31.6	6 mth	Description	Percentages
Tibben et al 19 ^‡	73	29/44	32.1	Baseline, 1 wk, 6 mth	Course	MANOVA
Tibben et al 20 ^‡	49	20/29	32.2	Baseline, 1 wk, 6 mth, 3 y	Course	MANOVA
DudokdeWit et al ⁹ ^§	25	9/16	39.5	Baseline, 1 wk, 6 mth	Course	MANOVA
DudokdeWit et al 10 ^§	25	9/16	39.5	Baseline, 6 mth	Prediction	Multiple regression analysis
Leuven
Decruyenaere et al ⁸	53	22/31	34	Baseline, 1 mth, 12 mth	Prediction, course	Multiple regression analysis,t tests
Indianapolis
Quaid and Wesson15	19	5/14	36.9	Baseline, 3 mth, 6 mth, 9 mth, 12 mth	Comparison of groups	Mann-Whitney U test

↵1-150 Genetic status not assessable in linkage test.
↵1-151 ^‡ ^§Same population.
NA: not applicable.