Subtelomeric studies of patients with idiopathic mental retardation
| Reference | No of patients | Selection criteria | No of subtelomeric rearrangements detected | Prevalence (%) | |||||
|---|---|---|---|---|---|---|---|---|---|
| High resolution studies | Subtelomeric FISH | ||||||||
| 38 | 17 | Mental retardation, dysmorphic features, and minor criteria, eg family history suggestive of inherited disorder, convulsive and behavioural disorders | ND | 4 | 23.0 | ||||
| 37 | 209 | Mild and severe mental retardation and congenital abnormalities | ND | 8 | 3.8 | ||||
| 34 | 44 | 27 with severe mental retardation, 31 with dysmorphic features, 14 with positive family history | ND | 6 | 13.0 | ||||
| 35 | 93 | Idiopathic mental retardation | 2 | 0 | 2.2 | ||||
| 36 | 43 | Mental retardation and dysmorphic features | 0 | 1 | 2.3 | ||||
| High resolution banding normal | |||||||||
| 33 | 284 | Moderate to severe idiopathic mental retardation | ND | 21 | 7.4 | ||||
| 182 | Idiopathic mild mental handicap | ND | 1 | 0.5 | |||||
ND = not done.