Table 1

Results of two point linkage analysis and model free tests of association (SimIBD and TDT)

Markers		cM map		Lod scores θ				p values associated with
Markers		cM map		0.00	0.01			0.05	0.10	0.20	0.30	0.40	SimIBD	TDT
D11S916	80	−10.08	−2.90	−1.00	−0.33	+0.06	+0.08	+0.01		0.28	0.69
D11S911	84	+2.33	+2.29	+2.10	+1.85	+1.34	+0.82	+0.33		0.03	0.06
D11S937	85	+2.33	+2.29	+2.10	+1.85	+1.34	+0.82	+0.33		0.01	0.06
D11S918	87	+1.01	+0.98	+0.88	+0.75	+0.50	+0.27	+0.10		0.10	0.50
D11S901	89.5	+3.55	+3.49	+3.23	+2.89	+2.16	+1.39	+0.64		0.01	0.06
D11S4187	90.1	+1.52	+1.49	+1.34	+1.15	+.077	+0.40	+0.12		0.03	0.13
D11S4135	90.9	+0.001	+0.001	+0.001	+0.008	+0.004	+0.001	+0.000		0.50	1.00
D11S4147	91.7	+2.33	+2.29	+2.10	+1.85	+1.34	+0.82	+0.33		0.02	0.06
D11S1354	91.7	+2.61	+2.56	+2.33	+2.04	+1.45	+0.86	+0.34		0.02	0.06
D11S1979	91.7	+3.21	+3.15	+2.90	+2.58	+1.90	+1.19	+0.48		0.02	0.01
D11S1887	92.2	+2.81	+2.75	+2.51	+2.21	+1.59	+0.97	+0.41		0.03	0.13
D11S1780	93.7	+3.21	+3.15	+2.88	+2.55	+1.85	+1.13	+0.44		0.01	0.02
D11S1367	94.3	−2.97	+0.30	+0.85	+0.95	+0.82	+0.55	+0.25		0.05	0.37
D11S1974	94.8	−2.09	+1.15	+1.61	+1.60	+1.27	+0.80	+0.31		0.03	0.03
D11S4175	95	−3.05	+0.75	+1.22	+1.23	+0.94	+0.56	+0.23		0.07	0.50
D11S1358	96	+1.93	+1.89	+1.69	+1.44	+0.96	+0.52	+0.18		0.03	0.06
D11S1311	98	+.066	+0.65	+0.57	+0.47	+0.29	+0.15	+0.05		0.21	1.00
D11S919	101	−4.02	−0.01	+0.55	+0.66	+0.58	+0.37	+0.16		0.12	1.00

Disease: PPP with disease frequency of 0.0001 in a recessive model with reduced penetrance (95%) assuming equal allele frequencies at each marker locus.