Chromosome A | LOH 8p/ROH A | LOH% | LOH 8p/LOH A | LOH% | p value |
1p | 22/46 | 48 | 67/103 | 65 | 0.0482-150 |
3p | 36/86 | 42 | 66/87 | 76 | <0.0001*** |
6q | 23/64 | 36 | 50/68 | 74 | <0.0001*** |
7q | 38/92 | 41 | 34/50 | 68 | 0.002** |
9p | 34/81 | 42 | 38/49 | 78 | <0.0001*** |
11p | 25/46 | 54 | 24/26 | 92 | 0.001** |
11q | 26/50 | 52 | 44/73 | 60 | 0.36 |
13q | 11/40 | 28 | 53/69 | 77 | <0.0001*** |
16q | 25/55 | 45 | 54/93 | 58 | 0.137 |
17p | 14/31 | 45 | 15/19 | 79 | 0.0372-150 |
17q | 18/33 | 55 | 43/59 | 73 | 0.074 |
18q | 23/51 | 45 | 68/113 | 60 | 0.072 |
20q | 52/114 | 46 | 49/63 | 78 | <0.0001*** |
The first column shows the other 13 chromosome arms (A) analysed. The second and third columns show the fraction and percentage of tumours with 8p LOH in total tumours with ROH of chromosome A. The fourth and fifth columns show the fraction and percentage of tumours with 8p LOH in total tumours with LOH at the given chromosome A. The calculated p values are in the last column (chi-square).
ROH: retention of heterozygosity.
↵2-150 95% confidence interval. **99% confidence interval. ***99.9% confidence interval.