Transfected PTEN constructs | Mean colony counts (SD) | Colony size | |||||
---|---|---|---|---|---|---|---|
Cell line BT-5493-150 | Cell line MDA-MB-4683-150 | Cell line BT-549 | Cell line MDA-MB-468 | ||||
Vector only (control) | 275 (22.7)3-151 | 97.7 (10.9)3-151 | Large | Large | |||
PTEN mutant C124S (phosphatase inactive) | 278.3 (5.6)3-151 | 85 (9.3)3-151 | Large | Large | |||
PTEN mutant V119L (M1) | 185 (9.3)3-151 | 10.3 (4.4) | Intermediate | Small | |||
PTEN mutant V158L (M2) | 195 (10.7)3-151 | 11.7 (2.4) | Intermediate | Small | |||
Wild type PTEN | 61.7 (2.9) | 6.7 (2.9) | Small | Small |