Characteristic
|
Somatic mosaic
|
Sporadic non-mosaic
|
p
|
No of patients | 13 | 86 | |
Age at onset of symptoms, years, mean (SE) | 26.5 (2.4) | 18.7 (1.1) | 0.012 |
Age at diagnosis, years, mean (SE) | 33.6 (2.7) | 24.7 (1.3) | 0.013 |
Germline mutation type (%) | | | 0.055 |
Frameshift or nonsense | 92.3 | 62.8 | |
Other | 7.7 | 37.2 | |
Vestibular schwannomas (%) | | | 0.391 |
None or unilateral | 30.0 | 12.9 | |
Bilateral | 70.0 | 87.1 | |
Spinal tumours (%) | | | 0.733 |
Absent | 30.8 | 24.4 | |
Present | 69.2 | 75.6 | |
Intracranial meningiomas (%) | | | 0.773 |
Absent | 46.2 | 41.9 | |
Present | 53.8 | 58.1 | |
Intracranial meningiomas, number, mean (SE) | 1.5 (1.0) | 1.5 (0.2) | 0.993 |