Table 1

Characteristics of somatic mosaic and sporadic non-mosaic NF2 patients

Characteristic Somatic mosaic Sporadic non-mosaic p
No of patients1386
Age at onset of symptoms, years, mean (SE)26.5 (2.4)18.7 (1.1)0.012
Age at diagnosis, years, mean (SE)33.6 (2.7)24.7 (1.3)0.013
Germline mutation type (%)0.055
 Frameshift or nonsense92.362.8
 Other7.737.2
Vestibular schwannomas (%)0.391
 None or unilateral30.012.9
 Bilateral70.087.1
Spinal tumours (%)0.733
 Absent30.824.4
 Present69.275.6
Intracranial meningiomas (%)0.773
 Absent46.241.9
 Present53.858.1
Intracranial meningiomas, number, mean (SE)1.5 (1.0)1.5 (0.2)0.993