Table 1

Consensus sequences for motifs shared between the fibrillins and the LTBPs. Consensus sequences were determined from sequences taken from the references cited in fig 1. In the consensus sequences, X may be any residue and the numbers in parentheses indicate an average number of residues

Motif Proteins Consensus sequence
EGFFibrillin-1,2, LTBP-1, -2, -3, -4C-X(3)-C-X(4-5)-C-X(4-5)-C-X-C-X(8)-C
cbEGFFibrillin-1,2, LTBP-1, -2, -3, -4X-D-X-(N/D)-E-C-X(6)-C-X(4)-C-X-N*-X(2)-G-X-(Y/F)-X-C-X-C-X(2)-G-X(9)-C
LTBPFibrillin-1,2, LTBP-1, -2, -3, -4X(3-21)-C-(Y/F/W)-X(7-8)-C-X(12-13)-C-C-C-X(8)-C-X(2-4)-C-P-X(9-10)-C
FibFibrillin-1,2, LTBP-1, -2, -3, -4X(6)-C-(Y/F/W)-X(7-8)-C-X(12-13)-C-C-X(10-11)-C-X(2)-C-X(5-21)-C-X(2)-G-X(7-8)C
Fib 4-cys motifFibrillin-1,2, LTBP-2N-V-C-G-X(2-6)-C-C-P-G-W-X(6-8)-C-I-X-P
LT 4-cys motifLTBP-2, -3I-C-K-R-C-X(4)-C-X2-S-C-X(21-24)