The impact of different cut off levels on the number of probands to be selected for germline mutation analysis using the algorithm of Wijnen et al.11 The total number of probands scrutinised was 509
| Cut off level | Mutation positive probands exceeding the cut off level | Total number of probands exceeding the cut off level | |||||
|---|---|---|---|---|---|---|---|
| p1 | p2 | p1 | p2 | ||||
| 20% | 1/10 | 3/10 | 2 | 6 | |||
| 15% | 2/10 | 5/10 | 4 | 8 | |||
| 10% | 4/10 | 7/10 | 6 | 23 | |||
| 5% | 6/10 | 10/10 | 21 | 52 | |||