Table 1

Two point lod scores for families 26, 27, and 28 for markers from four known ADPHSP loci. For each locus, the physical order of markers corresponds to their order in the table. Lod scores are not given for the chromosome 2 markers at θ=0.1, since the critical region for this locus is only 3 cM in length. In view of the age dependent penetrance of ADPHSP, two point linkage analysis for each marker was carried out on an affected only basis, using the MLINK programme of the FASTLINK version 3.0P package. Multipoint analysis was carried out using the LINKMAP program of the FASTLINK package. Allele frequencies were determined by genotyping a panel of unrelated spouses

		Family 26			Family 27			Family 28
		θ			θ			θ
		0	0.05		0.1	0		0.05	0.1	0	0.05	0.1
D2S400	−∞	−1.44		0.32	0.27		0.10	0.08
D2S352	−∞	−1.32		1.32	1.10		−∞	−0.91
D2S367	−∞	−1.44		2.22	2.01		−∞	−1.68
D8S1804	−∞	−1.48	−0.91				−∞	−0.40	0.05
D8S1799	−∞	−1.26	−0.74				−∞	−1.24	−0.49
D8S266	−∞	−2.03	−1.27				0.11	0.09	0.07
D14S1053				−∞	−0.01	0.11
D14S1013				−∞	0.47	0.58
D14S288	−3.7	−0.58	−0.32	1.54	1.37	1.21	−∞	−3.43	−2.28
D14S269	−∞	−1.24	−0.72	−∞	−0.28	−0.07	−∞	−2.15	−1.33
D14S281	−∞	−1.44	−0.89	−∞	−0.44	0.00	−∞	−1.72	−1.14
D15S128	−∞	−1.25	−0.73	−∞	−0.45	−0.02	−∞	−2.15	−1.33
D15S122	−∞	−1.25	−0.73	−∞	0.34	0.50	−∞	−0.44	−0.19
D15S156	−∞	−1.26	−0.73	−∞	−0.81	−0.38	−∞	−0.44	−0.19