Families | Patients with CMM | Patients with CMM and DN | Patients with >1 primary CMM | Mean age at first diagnosis | CDKN2A mutations (%)1-150 | |
---|---|---|---|---|---|---|
Familial | 34 | 56 | 27 | 7 | 35.7 | 6/34 (17) |
⩾3 AFM (first degree relatives) | 9 | 23 | 11 | 3 | 39.9 | 3/9 (33) |
CMM | 2 | 6 | 0 | 0 | 42 | 1/9 (11) |
CMM/DN | 7 | 17 | 11 | 3 | 38.9 | 2/9 (22) |
2 AFM (first degree relatives) | 15 | 21 | 10 | 1 | 42.2 | 2/15 (13) |
CMM | 3 | 3 | 0 | 0 | 45 | 0/15 |
CMM/DN | 12 | 18 | 10 | 1 | 39.5 | 2/15 (13) |
2 AFM (second degree relatives) | 3 | 5 | 0 | 0 | 37 | 0/3 |
1 AFM associated with DN | 7 | 7 | 6 | 3 | 25 | 1/10 (10) |
Sporadic | 0 | 9 | 4 | 5 | 55 | 0/9 |
Multiple CMM | 0 | 5 | 3 | 5 | 53 | 0/5 |
CMM and other neoplasias1-151 | 0 | 4 | 1 | 0 | 57 | 0/4 |