Some regions of interest from molecular genetic linkage studies of bipolar disorder
| Chromosomal location | Study reference | Comment |
|---|---|---|
| 4p16 | 117 | Single large UK pedigree with max lod = 4.8 |
| 118 | Single moderate size UK pedigree (schizoaffective disorder) with max lod =1.9 | |
| 12q23-q24 | 119 | Single UK pedigree in which Darier’s disease120 121 and bipolar disorder cosegregate. Max lod = 2.1 |
| 122 | 29 small-moderate UK pedigrees. Max lod = 2.0. No evidence in 16 German families | |
| 123 | Single very large pedigree from an isolated French Canadian community. Max lod = 4.9 | |
| 124 | 2 moderate size Danish pedigrees. Max lod = 3.4 | |
| 18 centromeric | 125 | 22 moderate size US pedigrees. Max non-parametric evidence p<0.0001 |
| 126 | 28 moderate size US pedigrees (particularly those showing paternal transmission). Max non-parametric evidence p<0.001 | |
| 18q22 | 126 | 28 moderate size US pedigrees (particularly those showing paternal transmission). Max sib pair evidence p<0.001 |
| 18q22-q23 | 127 | 2 large Costa Rican pedigrees. Max lod for combined linkage association = 4.06 |
| 21q22 | 128 | Single large US pedigree. Max lod = 3.4 |
| 129 | 22 moderate size US pedigrees (particularly those showing maternal transmission). Max sib pair evidence p<0.001 | |
| 130 | 97 moderate size US pedigrees. Max sib pair evidence p<0.001 | |
| 131 | 23 UK & Icelandic pedigrees. Max lod = 2.2 |
This table illustrates some current regions of interest. Readers seeking a systematic overview of findings including both negative and positive reports should consult Chromosome Workshop reports (see text).