Pairwise lod scores between the disease and 19p13 markers
| Locus | Lod score at θ | |||||||
|---|---|---|---|---|---|---|---|---|
| 0.00 | 0.01 | 0.05 | 0.1 | 0.2 | 0.3 | 0.4 | Zmax | |
| D19S586 | 1.88 | 1.86 | 1.75 | 1.58 | 1.14 | 0.68 | 0.27 | 1.88 |
| D19S221 | 3.29 | 3.23 | 2.97 | 2.63 | 1.89 | 1.13 | 0.46 | 3.29 |
| SCA6/CAG | 6.89 | 6.78 | 6.33 | 5.74 | 4.46 | 3.03 | 1.47 | 6.89 |
| D19S714 | −0.89 | 1.32 | 1.77 | 1.73 | 1.30 | 0.73 | 0.22 | 1.77 |
| D19S433 | −∞ | −4.94 | −2.24 | −1.20 | −0.39 | −0.10 | −0.001 | −0.001 |
Pairwise linkage analysis was performed using the FASTLINK computer package version 2.1.14 A gene frequency of 0.0001 and equal female and male recombination values were considered. Each asymptomatic at risk subject was assigned to one of the six age dependent liability classes obtained from family data according to the age at onset curve: class 1 = 0 (<40), class 2 = 0.12 (40–45), class 3 = 0.37 (46–50), class 4 = 0.70 (51–55), class 5 = 0.96 (56–60), and class 6 = 1.0 (>60). A disease penetrance of 99% was reached at 60 years.