Risk factor | Mutation carriers (n=27) | Non-carriers (n=144) | p value2-150 |
---|---|---|---|
Proband associated variables | |||
Diagnosis <50 y | 22 (81.5%) | 67 (46.5%) | 0.001 |
Bilateral breast cancer | 5 (18.5%) | 11 (7.6%) | NS |
Breast + ovarian cancer | 2 (7.4%) | 0 (—) | 0.02 |
Family history: relatives diagnosed with breast or ovarian cancer | |||
1° (any age) | 11 (40.7%) | 40 (27.8%) | NS |
1° (dx <60 y) | 10 (37.0%) | 21 (14.6%) | 0.012 |
2° (any age) | 12 (44.4%) | 49 (34.0%) | NS |
2° (dx <60 y) | 8 (29.6%) | 26 (18.1%) | NS |
1° and 2° (any age) | 5 (18.5%) | 17 (11.8%) | NS |
1° or 2° (any age) | 18 (66.7%) | 72 (50.0%) | NS |
1° or 2° (dx <60 y) | 15 (55.6%) | 44 (30.6%) | 0.016 |
Family history of ovarian cancer | |||
9 (33.3%) | 4 (2.8%) | <0.001 |
↵2-150 p values from Fisher’s exact test.