Table 1

Rheumatoid arthritis status, TNF/LT haplotype status, and screening method(s) for each subject studied

SubjectRA statusTNF/LT haplotype*PCR-SSCP analysis/NIRCADNA sequencing
1† §,3† ‡ +H1/H1TT
2† +H1/H1NTT
4† ‡ +H1/H1TNT
5† ‡,7+H2/H2TT
6+H1/H39TT
8† ‡,9† +H2/H2TNT
10+H2/H1TT
11,12+H2/H1TNT
13+H2/H8TT
14+H1H37TNT
15+H1/H22TNT
16+H6/H43TNT
17+H24/H2TNT
18+H33/H43TNT
19+H2/H28TNT
20† -H1/H1NTT
21† -H9/H9TNT
22† -H6/H6TNT
23-H43/H43TNT
24-H24/H24NTT
25-H19/H35NTT
26-H34/H43NTT
27-H19/H22TNT
28-H1/H48TNT
29-H8/H24TNT
30-H34/H15TNT
31-H2/H2TNT
32† §,33† § +H8/H1TNT
34† § -H43/H1TNT
35† ,36† +H26/H1TNT
37† +H26/H45TNT
38† -H33/H1TNT

  • T, tested, NT, not tested. *TNF/LT microsatellite haplotypes were defined as follows: H1: a6, b5, c1, d3, e3, H2: a2, b3, c1, d3, e1, H6: TNF a2, b1, c1, d3, e3, H8: a2, b1, c2, d4, e1, H9: a2, b1, c2, d4, e3, H15: a2, b5, c1, d1, e3, H19: a2, b5, c2, d4, e3, H22: a4, b5, c1, d3, e3, H24: a4, b7, c2, d5, e3, H26: a5, b5, c2, d3, e2, H28: a6, b3, c1, d3, e3, H33: a7, b4, c1, d3, e3, H34: a8, b4, c1, d3, e3, H35: a9, b4, c2, d2, e3, H37: a10, b3, c2, d4, e3, H39: a10, b4, c1, d3, e3, H43: a11, b4, c1, d3, e3, H45: a12, b4, c1, d3, e3, H48: a11, b4, c1, d4, e3., †UK origin. ‡Sibs. § Family A. Family B. All subjects of Irish origin unless otherwise indicated.