The aim of the North Cumbria Community Genetics Project is to establish a store of DNA, plasma, and viable cells from a cohort of around 8000 Cumbrian infants. To meet this objective, specimens of umbilical cord blood and tissue will be collected with maternal consent from babies born at the West Cumberland Hospital, Whitehaven over a five year period from January 1996. These samples will be used in a series of genetic and epidemiological studies investigating the interaction between genes, the environment, and health. There is little population movement in West Cumbria and so it will be possible to follow many of the babies throughout their childhood and to investigate the relationship between their genetic constitution and health outcome.