The synapsin cycle: a view from the synaptic endocytic zone

J Neurosci Res. 2007 Sep;85(12):2648-56. doi: 10.1002/jnr.21176.

Abstract

Although the synapsin phosphoproteins were discovered more than 30 years ago and are known to play important roles in neurotransmitter release and synaptogenesis, a complete picture of their functions within the nerve terminal is lacking. It has been shown that these proteins play an important role in the clustering of synaptic vesicles (SVs) at active zones and function as modulators of synaptic strength by acting at both pre- and postdocking levels. Recent studies have demonstrated that synapsins migrate to the endocytic zone of central synapses during neurotransmitter release, which suggests that there are additional functions for these proteins in SV recycling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axonal Transport / physiology
  • Models, Biological
  • Neurons / metabolism
  • Neurons / ultrastructure
  • Neurotransmitter Agents / metabolism
  • Synapses / metabolism*
  • Synapses / ultrastructure
  • Synapsins / metabolism*
  • Synaptic Vesicles / metabolism*
  • Synaptic Vesicles / ultrastructure

Substances

  • Neurotransmitter Agents
  • Synapsins