Abstract
On demand, rapid Ca(2+)-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency-based fusion differs fundamentally from other rapid, triggered fusion reactions. Emergency fusion might use a specialized protein and organelle emergency response team that can simultaneously promote impromptu homotypic fusion events between organelles and exocytic fusion events along the vertices between these fusion products and the plasma membrane.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Calcium / metabolism
-
Calcium Signaling / physiology*
-
Cell Membrane / chemistry
-
Cell Membrane / metabolism*
-
Cell Membrane / pathology*
-
Dysferlin
-
Lysosomes / metabolism
-
Membrane Fusion / physiology*
-
Membrane Proteins / genetics
-
Membrane Proteins / metabolism
-
Muscle Proteins / genetics
-
Muscle Proteins / metabolism
-
Oocytes / cytology
-
Oocytes / metabolism
-
Sea Urchins
Substances
-
DYSF protein, human
-
Dysferlin
-
Membrane Proteins
-
Muscle Proteins
-
Calcium