Matrix metalloproteinases: a tail of a frog that became a prince

Constance E Brinckerhoff; Lynn M Matrisian

doi:10.1038/nrm763

Matrix metalloproteinases: a tail of a frog that became a prince

Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14. doi: 10.1038/nrm763.

Authors

Constance E Brinckerhoff¹, Lynn M Matrisian

Affiliation

¹ Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

PMID: 11994741
DOI: 10.1038/nrm763

Abstract

It is 40 years since the first member of what came to be known as the matrix metalloproteinase (MMP) family was described. Structural, molecular and biochemical approaches have subsequently contributed to piecing together the puzzle of how MMPs work, and how they contribute to various disease processes.

Publication types

Historical Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cloning, Molecular
Gene Expression Regulation, Enzymologic
History, 20th Century
Humans
Matrix Metalloproteinases / chemistry
Matrix Metalloproteinases / genetics
Matrix Metalloproteinases / history
Matrix Metalloproteinases / physiology*
Models, Biological
Models, Molecular
Protease Inhibitors / therapeutic use

Substances

Protease Inhibitors
Matrix Metalloproteinases