Effects of apolipoprotein E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women☆
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Cited by (26)
Interindividual variability in response to diet: Are genes involved?
2016, Cahiers de Nutrition et de DietetiqueVariation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat
2006, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :Recent interest has centred around gene–nutrient interactions in response of plasma lipid concentrations to changes in dietary fat and/or cholesterol, with particular emphasis on candidate genes known to play key roles in lipid metabolism. Variation in the genes for apolipoprotein (APO) A-I [25–30]; APOA-IV [26,29–31]; APOB [20,29,30,32–34]; APOE [16,27,29,30,35–43]; APOC-III [27,29,30,44,45]; lipoprotein lipase [29,30,46–48] and CETP [29,30,47] have all been reported to explain some of the variation in response to dietary changes. We found that individuals with the CETP B1B1 genotype showed an average change in TC and LDL-C when switching from a high saturated to a high polyunsaturated fat diet, which was approximately double than that observed in those with one or more CETP B2 allele [47].
Quantile-specific heritability of high-density lipoproteins with implications for precision medicine
2020, Journal of Clinical LipidologyCitation Excerpt :All 4 studies suggest that reducing HDL cholesterol by exchanging carbohydrate for fat produces smaller APOE genotype differences. Specifically, Nicklas et al. reported that noncarriers of the APOE ε4 allele (ε4−) showed larger decreases in HDL cholesterol (−0.26 mmol/L) than carriers (−0.08 mmol/L, Fig. 3F histogram), in going from their usual diet to a low-fat, low-cholesterol AHA step 1 diet (Pinteraction < 0.01).30 Figure 4F’s graph shows the effect size (ε4 noncarriers minus carriers) was smaller on the step 1 than the usual diet (0.03 ± 0.06 vs 0.21 ± 0.07 mmol/L) in accordance with the lower average HDL cholesterol concentration of the step 1 diet (1.23 ± 0.03 vs 1.45 ± 0.04 mmol/L).
Association between APOE polymorphisms and lipid profile in Mexican Amerindian population
2019, Molecular Genetics and Genomic Medicine
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Supported by National Institutes of Health (NIH) Grants No. RO1 NR03514 (to K.E.D.), R29 AG14066 (to B.J.N.), R01 DK46206 (to R.E.F.), and the Department of Veterans Affairs Baltimore GRECC (to A.P.G.).