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  • Original Paper
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Mouse models for colorectal cancer

Oncogene volume 18, pages 5325–5333 (1999)Cite this article

Abstract

Colorectal cancer (CRC) is one of the most common cancers in the Western world. Much has been learned about colorectal cancer from human inherited syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC). Mouse models for CRC were generated by introducing mutations into the mouse genes, whose human counterparts were implicated in the onset and progression of CRC. Central among these are mice carrying mutations in the Adenomatous polyposis coli (Apc) gene. Although most of these Apc mutations share some common phenotypes as homozygous embryonic lethality and tumor predisposition, the severity of the tumor predisposition is variable. Mice with mutations in the mismatch repair genes, Msh2 and Mlh1, exhibit a mismatch repair defect and are predisposed to developing gastrointestinal cancer, lymphomas and tumors of other organ systems. Mice carrying a mutation in the Pms2 gene are predisposed to lymphomas and other tumors. Mice with a mutation in the Msh6 gene have a defect in base mismatch repair and show a tumor predisposition phenotype. Mice with mutations in Mlh1, Pms2 and Msh5 have defects in meiosis suggesting unique roles for these genes in gametogenesis.

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References

  • Akiyama Y, Sato H, Yamada T, Nagasaki H, Tsuchiya A, Abe R and Yuasa Y. . 1997 Cancer Res. 57: 3920–3923.

  • Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA and Liskay RM. . 1995 Cell 82: 309–319.

  • Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M, Shibata D and Liskay RM. . 1998 Cancer Res. 58: 1087–1089.

  • Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A Ashley T and Liskay RM. . 1996 Nat Genet. 13: 336–342.

  • Boyer JC, Umar A, Risinger JI, Lipford JR, Kane M, Yin S, Barrett JC, Kolodner RD and Kunkel TA. . 1995 Cancer Res. 55: 6063–6070.

  • Bullions LC and Levine AJ. . 1998 Curr. Opin. Oncol. 10: 81–87.

  • Burt RW. . 1996 Gastroenterol Clin. North Am. 25: 793–803.

  • Chawengsaksophak K, James R, Hammond VE, Kontgen F and Beck F. . 1997 Nature 386: 84–87.

  • Clarke AR, Cummings MC and Harrison DJ. . 1995 Oncogene 11: 1913–1920.

  • de Wind N, Dekker M, Berns A, Radman M and te Riele H. . 1995 Cell 82: 321–330.

  • de Wind N, Dekker M, van Rossum A, van der Valk M and te Riele H. . 1998 Cancer Res. 58: 248–255.

  • Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP. . 1998 Nat. Genet 19: 348–355.

  • Dietrich WF, Lander ES, Smith JS, Moser AR, Gould KA, Luongo C, Borenstein N and Dove W. . 1993 Cell 75: 631–639.

  • Drummond JT, Li GM, Longley MJ and Modrich P. . 1995 Science 268: 1909–1912.

  • Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R, Pollard JW, Kolodner RD and Kucherlapati R. . 1996 Cell 85: 1125–1134.

  • Edelmann W, Cohen PE, Kneitz B, Winand N, Lia M, Heyer J, Kolodner R, Pollard JW and Kucherlapati R. . 1999a Nat. Genet 21: 123–127.

  • Edelmann W, Yang K, Kuraguchi M, Heyer J, Lia M, Kneitz B, Fan K, Brown AM, Lipkin M and Kucherlapati R. . 1999b Cancer Res. 59: 1301–1307.

  • Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R and Kucherlapati R. . 1997 Cell 91: 467–477.

  • Eng C and Peacocke M. . 1998 Nat. Genet 19: 223.

  • Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M and Weinberg RA. . 1997 Nature 386: 796–804.

  • Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M and Kolodner R. . 1993 Cell 75: 1027–1038.

  • Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM and Kucherlapati R. . 1994 Proc. Natl. Acad. Sci. USA 91: 8969–8973.

  • Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, McPherson J, Wasmuth J, Le Paslier D, Abderrahim H, Cohen D, Leppert M and White R. . 1991 Cell 66: 589–600.

  • Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE. . 1996 Science 271: 350–353.

  • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW. . 1998 Science 281: 1509–1512.

  • Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA and Baylin SB. . 1998 Proc. Natl. Acad. Sci. USA 95: 6870–6875.

  • Hioki K, Shivapurkar N, Oshima H, Alabaster O, Oshima M and Taketo MM. . 1997 Carcinogenesis 18: 1863–1865.

  • Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM and Aaltonen LA. . 1998 Science 280: 1086–1088.

  • Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, Groden J, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, McPherson J, Wasmuth J, Le Paslier D, Abderrahim H, Cohen D, Leppert M and White R. . 1991 Cell 66: 601–613.

  • Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, Finniear R, Markham A, Groffen J, Boguski MS, Altschul S, Horii A, Ando H, Miyoshi Y, Miki Y, Nishisho I and Nakamura Y. . 1991 Science 253: 661–665.

  • Kinzler KW and Vogelstein B. . 1996 Cell 87: 159–170.

  • Kolodner R. . 1996 Genes Dev. 10: 1433–1442.

  • Laird PW, Jackson-Grusby L, Fazeli A, Dickinson SL, Jung WE. Li E, Weinberg RA and Jaenisch R. . 1995 Cell 81: 197–205.

  • Li GM and Modrich P. . 1995 Proc. Natl. Acad. Sci. USA 92: 1950–1954.

  • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH and Parsons R. . 1997 Science 275: 1943–1947.

  • Lowsky R, DeCoteau JF, Reitmair AH, Ichinohasama R, Dong WF. Xu Y, Mak TW, Kadin ME and Minden MD. . 1997 Blood 89: 2276–2282.

  • Luongo C, Moser AR, Gledhill S and Dove WF. . 1994 Cancer Res. 54: 5947–5952.

  • Lynch HT and Smyrk T. . 1996 Cancer 78: 1149–1167.

  • MacPhee M, Chepenik KP, Liddell RA, Nelson KK, Siracusa LD and Buchberg AM. . 1995 Cell 81: 957–966.

  • Marcus DM, Rustgi AK, Defoe D, Brooks SE, McCormick RS, Thompson TP, Edelmann W, Kucherlapati R and Smith S. . 1997 Arch. Ophthalmol. 115: 645–650.

  • Miyaki M, Konishi M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, Yasuno M, Igari T, Koike M, Chiba M and Mori T. . 1997 Nat. Genet 17: 271–272.

  • Modrich P. . 1991 Ann. Rev. Genet 25: 229–253.

  • Modrich P and Lahue R. . 1996 Ann. Rev. Biochem. 65: 101–133.

  • Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C and Taketo M. . 1995 Proc. Natl. Acad. Sci. USA 92: 4482–4486.

  • Polakis P. . 1999 Curr. Opin. Genet Dev. 9: 15–21.

  • Prolla TA, Baker SM, Harris, AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A and Liskay RM. . 1998 Nat. Genet 18: 276–279.

  • Prolla TA, Christie DM and Liskay RM. . 1994a Mol. Cell. Biol. 14: 407–415.

  • Prolla TA, Pang Q, Alani E, Kolodner RD and Liskay RM. . 1994b Science 265: 1091–1093.

  • Reitmair AH, Cai JC, Bjerknes M, Redston M, Cheng H, Pind MT, Hay K, Mitri A, Bapat BV, Mak TW and Gallinger S. . 1996a Cancer Res. 56: 2922–2926.

  • Reitmair AH, Redston M, Cai JC, Chuang TC, Bjerknes M, Cheng H, Hay K, Gallinger S, Bapat B and Mak TW. . 1996b Cancer Res. 56: 3842–3849.

  • Reitmair AH, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrucker HW, Wakeham A, Liu B, Thomason A, Griesser H, Gallinger S, Ballhausen WG, Fishel R and Mak TW. . 1995 Nat. Genet 11: 64–70.

  • Ricciardone MD, Ozcelik T, Cevher B, Ozdag H, Tuncer M, Gurgey A, Uzunalimoglu O, Cetinkaya H, Tanyeli A, Erken E and Ozturk M. . 1999 Cancer Res. 59: 290–293.

  • Schena M, Shalon D, Heller R, Chai A, Brown PO and Davis RW. . 1996 Proc. Natl. Acad. Sci. USA 93: 10614–10619.

  • Schmutte C, Marinescu RC, Sadoff MM, Guerrette S, Overhauser J and Fishel R. . 1998 Cancer Res. 58: 4537–4542.

  • Shibata H, Toyama K, Shioya H, Ito M, Hirota M, Hasegawa S, Matsumoto H, Takano H, Akiyama T, Toyoshima K, Kanamaru R, Kanegae Y, Saito I, Nakamura Y, Shiba K and Noda T. . 1997 Science 278: 120–123.

  • Shoemaker AR, Luongo C, Moser AR, Marton LJ and Dove WF. . 1997 Cancer Res. 57: 1999–2006.

  • Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J and Mak TW. . 1998 Genes Dev. 12: 107–119.

  • Smits R, Kartheuser A, Jagmohan-Changur S, Leblanc V, Breukel C, de Vries A, van Kranen H, van Krieken JH, Williamson S, Edelmann W, Kucherlapati R, KhanPm and Fodde R. . 1997 Carcinogenesis 18: 321–327.

  • Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM and Fodde R. . 1999 Genes Dev. 13: 1309–1321.

  • Smits R, van der Houven van Oordt W, Luz A, Zurcher C, Jagmohan-Changur S, Breukel C, Khan PM and Fodde R. . 1998 Gastroenterology 114: 275–283.

  • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA and Dove WF. . 1992 Science 256: 668–670.

  • Su LK, Vogelstein B and Kinzler KW. . 1993 Science 262: 1734–1737.

  • Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M and Mak TW. . 1998 Curr. Biol. 8: 1169–1178.

  • Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF and Taketo MM. . 1998 Cell 92: 645–656.

  • Tetsu O and McCormick F. . 1999 Nature 398: 422–426.

  • Tishkoff DX, Amin NS, Viars CS, Arden KC and Kolodner RD. . 1998 Cancer Res. 58: 5027–5031.

  • Umar A, Boyer JC and Kunkel TA. . 1994 Science 266: 814–816.

  • Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM and Kunkel TA. . 1996 Cell 87: 65–73.

  • Velcich A, Corner G, Palumbo L and Augenlicht L. . 1999 Oncogene 18: 2599–2606.

  • Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeron C, Navarro C, Ruano E and Puisieux A. . 1999 Cancer Res. 59: 294–297.

  • Wasan HS, Novelli M, Bee J and Bodmer WF. . 1997 Proc. Natl. Acad. Sci. USA 94: 3308–3313.

  • Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B and Wainwright B. . 1998 Oncogene 17: 657–659.

  • Yagi OK, Akiyama Y and Yuasa Y. . 1999 Br. J. Cancer 79: 440–444.

  • Yang K, Edelmann W, Fan K, Lau K, Kolli VR, Fodde R, Khan PM, Kucherlapati R and Lipkin M. . 1997 J. Exp. Zool 277: 245–254.

  • Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, Kucherlapati R and Lipkin M. . 1998 Cancer Res. 58: 5713–5717.

  • Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B and Kinzler KW. . 1997 Science 276: 1268–1272.

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Authors and Affiliations

  1. Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA

    Joerg Heyer & Raju Kucherlapati

  2. Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA

    Winfried Edelmann

  3. Strang Cancer Prevention Center, New York, NY 10021, USA

    Kan Yang & Martin Lipkin

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Heyer, J., Yang, K., Lipkin, M. et al. Mouse models for colorectal cancer. Oncogene 18, 5325–5333 (1999). https://doi.org/10.1038/sj.onc.1203036

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