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No support for association between Dyslexia Susceptibility 1 Candidate 1 and developmental dyslexia

Molecular Psychiatry volume 10, pages 237–238 (2005)Cite this article

SIR—Several candidate chromosomal regions for developmental dyslexia (DD) have been identified,1 including a locus on chromosome 15q.2,3,4 The Dyslexia Susceptibility 1 Candidate 1 gene (DYX1C1, EKN1, Locus ID: 161582) was recently cloned from the 15q breakpoint of a translocation that cosegregates with DD in a single family.5,6 Two plausibly functional SNPs in the gene were subsequently shown to be associated with DD (−3G>A; P=0.002, 1249G>T; P=0.006; cases n=106; controls n=194),6 suggesting that DYX1C1 might be involved in susceptibility to DD in the general population. The data we present in this report, based on a DD sample showing association with 15q, do not support this hypothesis.

We genotyped the markers in a sample of 247 Caucasian, UK parent–proband trios (mean age=13.24 years, age range=7.92–17.17 years, IQ >85, reading ability >2.5 years behind chronological age). Full phenotypic measures are described elsewhere.4 SNPs were genotyped using Amplifluor.7 In keeping with another replication study,8 neither marker was associated with categorical DD (Table 1). We also found no evidence for association with marker rs11629841 (located in intron 4 of DYX1C1), which was associated with categorical DD in the latter study8 (P=0.018; n=83 families; 83 DD probands and 18 DD siblings).

Table 1 Transmissions of alleles at DYX1C1
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References

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  7. Myakishev MV et al. Genome Res 2001; 11: 163–169.

  8. Wigg KG et al. Mol Psychiatry 2004, Jul 13 [Epub ahead of print].

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Authors and Affiliations

  1. Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK

    N A Cope, G Hill, M van den Bree, D Harold, E K Green, M J Owen, J Williams & M C O'Donovan

  2. Bioinformatics and Biostatistics Unit, University of Wales College of Medicine, Cardiff, UK

    V Moskvina

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  1. N A Cope
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  2. G Hill
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  3. M van den Bree
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  4. D Harold
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  5. V Moskvina
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  6. E K Green
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  7. M J Owen
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  8. J Williams
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  9. M C O'Donovan
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Corresponding authors

Correspondence to J Williams or M C O'Donovan.

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Supplementary information accompanies the paper on Molecular Psychiatry website (http://www.nature.com/mp)

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Cope, N., Hill, G., van den Bree, M. et al. No support for association between Dyslexia Susceptibility 1 Candidate 1 and developmental dyslexia. Mol Psychiatry 10, 237–238 (2005). https://doi.org/10.1038/sj.mp.4001596

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