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Association between PRODH and schizophrenia is not confirmed

Molecular Psychiatry volume 8, pages 644–645 (2003)Cite this article

SIR – It has recently been reported that genetic variants of proline dehydrogenase (PRODH) increase susceptibility to schizophrenia.1 This is of interest since PRODH maps within the velo-cardio-facial syndrome (VCFS) region of 22q11, deletion of which is one of the strongest known risk factors for schizophrenia.2 We have examined this claim using two samples each with high power (>99%) to detect the effects reported. Our data suggest that genetic variation at PRODH is unlikely to be associated with even modestly increased risk of schizophrenia, and that the earlier report is the result of chance.

Liu et al1 reported association between various permutations of SNPs and haplotypes constructed from markers at positions 1766, 1945, and 2026 of PRODH in a small sample (n=107) of European-American schizophrenic proband–parent trios, in a second sample of 26 trios where the proband had a childhood onset illness, and in a third small sample of 109 adult Afrikaners and 75 controls. Their analysis suggested an association between schizophrenia and a ‘221’ haplotype at three loci 1766/1945/2026, defined by alleles G, T, and C, respectively, and this effect was strongest for disease of early onset.

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References

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Authors and Affiliations

  1. Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK

    H J Williams, N Williams, G Spurlock, N Norton, D Ivanov, A Preece, S Jones, S Zammit, A Thapar, K C Murphy, G Kirov, M J Owen & M C O'Donovan

  2. Department of Clinical Research, Crichton Royal Hospital, Dumfries, UK

    R G McCreadie & V Sharkey

  3. Medical University Sofia, Medical Genetics, Sofia, Bulgaria

    I Nikolov & I Kehaiov

Authors
  1. H J Williams
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  2. N Williams
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  3. G Spurlock
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  4. N Norton
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  5. D Ivanov
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  6. R G McCreadie
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  7. A Preece
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  8. V Sharkey
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  9. S Jones
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  10. S Zammit
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  11. I Nikolov
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  12. I Kehaiov
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  13. A Thapar
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  14. K C Murphy
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  15. G Kirov
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  16. M J Owen
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  17. M C O'Donovan
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Corresponding author

Correspondence to M C O'Donovan.

Additional information

Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

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Williams, H., Williams, N., Spurlock, G. et al. Association between PRODH and schizophrenia is not confirmed. Mol Psychiatry 8, 644–645 (2003). https://doi.org/10.1038/sj.mp.4001276

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  • DOI: https://doi.org/10.1038/sj.mp.4001276

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