Cell
Volume 126, Issue 2, 28 July 2006, Pages 239-241
Journal home page for Cell

Preview
MutLα: At the Cutting Edge of Mismatch Repair

https://doi.org/10.1016/j.cell.2006.07.003Get rights and content
Under an Elsevier user license
open archive

The mismatch repair process corrects errors in newly synthesized DNA. In this issue, Modrich and colleagues (Kadyrov et al., 2006) show that a component of the human mismatch repair machinery, MutLα, has endonuclease activity. MutLα introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXOI to degrade the strand containing the mismatch.

Cited by (0)