Cancer Letters

Cancer Letters

Volume 112, Issue 2, 30 January 1997, Pages 257-262
Cancer Letters

GSTM1 gene polymorphism as a possible marker for susceptibility to head and neck cancers among Japanese smokers

https://doi.org/10.1016/S0304-3835(96)04584-3Get rights and content

Abstract

Increased risk of lung cancer has been reported in individuals with glutathione S-transferase M1 (GSTM1) gene deletion, with limited evidence for head and neck (HN) cancer. Here, we report the results of a case-control study in Japanese HN cancer patients (n = 158) and community controls (n = 174). GSTM1 null genotype (GSTM1(−)) was distributed more in smoker patients than in control subjects (56.7% vs. 48.5%) but not in non-smoker patients (48.3%). In smokers, GSTM1(−) was detected at increased frequency in non-larynx cancer (62.7%, odds ratio 1.77, 95% CI 1.04–3.01) but not in larynx cancer (48.1%). In larynx cancer GSTM1(–) was presented at higher frequency in patients <60 years old than in those ≥60 years old (78.6% vs. 36.8%). These findings suggest that the GSTM1 gene polymorphism potentially modifies the risk for HN cancer depending on smoking history, the region of cancer and age.

References (31)

  • B. Ketterer

    Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis

    Mutat. Res.

    (1988)
  • A. Lafuente et al.

    Human glutathione S-transferase m (GSTm) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers

    Cancer Lett.

    (1993)
  • Z. Trizna et al.

    Glutathione S-transferase genotypes as risk factors for head and neck cancer

    Am. J. Surg.

    (1995)
  • S. Akiba et al.

    Cigarette smoking and cancer mortality risk in Japanese men and women: results from reanalysis of the six-prefecture cohort study data

    Environ. Health Perspect.

    (1990)
  • A.-K. Alexandrie et al.

    Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types

    Carcinogenesis

    (1994)
  • D.A. Bell et al.

    Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer

    J. Natl. Cancer Inst.

    (1993)
  • P. Board et al.

    Genetic heterogeneity of the human glutathione transferases: a complex of gene families

    Pharmacol. Ther.

    (1990)
  • J. Brockmoller et al.

    Genotype and phenotype of glutathione S-transferase class mu isoenzymes μ and ι in lung cancer patients and controls

    Cancer Res.

    (1993)
  • N. Caporaso et al.

    Lung cancer and CYP2D6 (the debrisoquine polymorphism): source of heterogeneity in the proposed association

    Pharmacogenetics

    (1995)
  • C.-J. Chen et al.

    Multiple risk factors of nasopharyngeal carcinoma: Epstein-Barr virus, malarial infection, cigarette smoking and familial tendency

    Anticancer Res.

    (1990)
  • S. Hayashi et al.

    High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and Mu-class glutathione S-transferase genes

    Jpn. J. Cancer Res.

    (1992)
  • S.R. Heckbert et al.

    Glutathione S-transferase and epoxide hydroxylase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers

    J. Natl. Cancer Inst.

    (1992)
  • A. Hirvonen et al.

    The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung

    Carcinogenesis

    (1993)
  • W.M. Keane et al.

    Epidemiology of head and neck cancer

    Laryngoscope

    (1981)
  • M. Kihara et al.

    Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure

    Carcinogenesis

    (1994)
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