Elsevier

The Lancet

Volume 356, Issue 9240, 28 October 2000, Pages 1490-1491
The Lancet

Research Letters
Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

https://doi.org/10.1016/S0140-6736(00)02877-4Get rights and content

Summary

Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0·003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.

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