Original article
A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly**

https://doi.org/10.1016/S0022-3476(74)80675-XGet rights and content

Two strikingly similar unrelated male children have the following pattern of anomalies: accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly. The craniofacial abnormalities include large ears, broad forehead with hypertelorism, and long philtrum in relation to the relatively small mouth and mandible. The excessive growth is of prenatal onset and has continued at two to three times the normal rate with dysharmonic acceleration of skeletal maturation.

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Supported by grants from: Maternal and Child Health Services, Health Services and Mental Administration, Department of Health, Education and Welfare, Project 913; National Institutes of Health Grant No. HD 05961; and The National Foundation-March of Dimes.

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