Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy
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2014, Metabolic EngineeringCitation Excerpt :This experimental set-up resulted in lower basal expression of the BEARON system, suggesting that the basal leakiness indeed originates in part from bile salts contained in serum supplements (Fig. 1D). The BEAROFF as well as the BEARON systems were responsive within the clinically relevant concentration range (pathological serum levels are between 10 and 300 µM; Bacq et al., 1995; Glantz et al., 2004; Palmeira and Rolo, 2004), indicating that the gene switches could double as biosensors detecting pathological bile acid levels in future clinical applications. Because ON-type gene switches are the preferred configuration for biosensor circuits as well as transgene expression fine-tuning in vitro, we used the BEARON system in all follow-up experiments.
Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease
2011, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Moreover, combined polymorphisms on FXR and BSEP can result in short cholestasis episode early in life and ICP [202]. During ICP, CA levels—a good FXR ligand—are increased and the ratio CA/CDCA was identified as ICP indicator [203–205]. It is therefore plausible that ICP might represent a disease in a population where FXR, or FXR cofactors, and/or FXR target genes polymorphisms contribute to abnormal FXR activation.
Computerized cardiotocography and short-term variation in management of obstetric cholestasis: A useful tool?
2011, Journal de Gynecologie Obstetrique et Biologie de la ReproductionCholestasis of pregnancy
2010, Obstetrics and Gynecology Clinics of North AmericaCitation Excerpt :Furthermore, there are differences in the methodologies used to measure total serum TBA concentration. Depending on methodology, the mean serum TBA concentrations in the third trimester of pregnancy appear to be approximately 1.8 ± 2.2 μmol/L (range 0.5–12.0) using direct spectrophotometry and 6.5 μmol/L (2 SD range 1.7–11.3) using enzymatic methods.31,32 Other laboratory abnormalities observed in ICP include elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase, and bilirubin.26,29
Gastrointestinal and Hepatic Disorders in the Pregnant Patient
2010, Sleisenger and Fordtran’s Gastrointestinal and Liver Disease- 2 Volume Set: Pathophysiology, Diagnosis, Management, Expert Consult Premium Edition - Enhanced Online Features and PrintMechanisms of Cholestasis
2008, Clinics in Liver DiseaseCitation Excerpt :Abnormalities in progesterone metabolism may also play a major role in the pathogenesis ICP. This is emphasized by the observed association of ICP with progesterone treatment in the third trimenon [44]. In addition, the levels of sulfated progesterone metabolites are increased in ICP and the profiles of sulfated progesterone metabolites differ between normal pregnancy and ICP [45,46].