Clinical Immunology and Immunopathology
Evidence that celiac disease is primarily associated with a DC locus allelic specificity
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Cited by (163)
Celiac disease susceptibility: The genome and beyond
2021, International Review of Cell and Molecular BiologyCitation Excerpt :Here we revisit the Genomics of CeD from GWAS to the Microbiome regulation exerted by the Genetic landscape of the host. The first genetic studies describing the association between CeD and HLA genes were carried out in the early 70’s (Falchuk et al., 1972; Stokes et al., 1972), and one decade later the alleles-encoding HLA-DQ2 were identified (Sollid et al., 1989; Tosi et al., 1983). For a long time, neither the candidate gene approaches in case-control cohorts nor the linkage studies in families were able to identify additional genetic factors outside the well-known HLA-DQ genes.
T cell receptor repertoire as a potential diagnostic marker for celiac disease
2021, Clinical ImmunologyCitation Excerpt :Celiac disease (CD) is a chronic HLA-associated inflammatory disorder that primarily affects the small intestine. The disease shows strong genetic association with HLA class II alleles encoding HLA-DQ2.5 (HLA-DQA1*05/HLA-DQB1*02, expressed by 90% of patients), HLA-DQ8 (HLA-DQA1*03/HLA-DQB1*03:02), and HLA-DQ2.2 (HLA-DQA1*02:01/HLA-DQB1*02) [9–11]. The epitopes of the causative antigen gluten are well defined and gluten-specific CD4 T cells that are only found in the small intestine of celiac disease patients, but not in healthy controls, have been isolated and extensively studied.
The genetics of celiac disease: A comprehensive review of clinical implications
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