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Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency

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Abstract

Sardinian males with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency have lower serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB), compared to normals. Since the enzyme deficiency is expressed also in nucleated cells, we studied cholesterol (C) and DNA synthesis and LDL-receptor expression in freshly isolated circulating mononuclear cells from normal and G-6-PD-deficient Sardinians. Synthesis of C (as 14C-acetate incorporation) and of DNA (as 3H-thymidine incorporation) was clearly reduced, both in basal state and after PHA stimulation, in G-6-PD-deficient cells compared to normal cells. On the other hand, no clear influence of G-6-PD deficiency on LDL-receptor expression could be demonstrated. The Mediterranean variant of G-6-PD deficiency is characterized, whatever the metabolic mechanism may be, by a serum lipoprotein pattern of reduced atherogenicity.

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Muntoni, S., Batetta, B., Dessi, S. et al. Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency. Eur J Epidemiol 8 (Suppl 1), 48–53 (1992). https://doi.org/10.1007/BF00145349

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