MinireviewEvolution and Diversity of Mammalian Sodium Channel Genes☆
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Cited by (176)
Crystal structure analysis, Hirshfeld surface analysis, spectral investigations (FT-IR, FT-R), DFT calculations, ADMET studies and molecular docking of 3H-Methyl-1H-pyrazole-1-carboxamide (3MPC)
2022, Journal of the Indian Chemical SocietyCitation Excerpt :The membrane potentials of Nav channels switch between closed, open, and inactivated states [2]. SCNXA genes encode nine subtypes (Nav1.1 to 1.9, respectively) [3,4]. Nav1.1–Nav1.3 and Nav1.6 are the most common subtypes of the human central nervous system, Nav1.7–1.9 in the peripheral nervous system, Nav1.5 in the heart, and Nav1.4 in skeletal muscle.
Membrane transport: Voltage-gated sodium channels: Structure, function, and pathophysiology
2021, Encyclopedia of Biological Chemistry: Third EditionNormal audiogram but poor sensitivity to brief sounds in mice with compromised voltage-gated sodium channels (Scn8a <sup>medJ</sup> )
2019, Hearing ResearchCitation Excerpt :These channels are encoded by at least 10 genes, and several modifications of those genes in rodents have been used to explore the consequences of pinpoint mutations of this complex molecule (e.g., Caldwell et al., 2000; Mackenzie et al., 2009). The Scn8amedJ mutation is one such mutation; it reduces Scn8a voltage-gated sodium channels to 10% of their wildtype levels and causes abnormal conduction times, tremors, and motor weakness (Caldwell et al., 2000; Chen et al., 2009; Plummer and Meisler, 1999). In addition to the obvious motor abnormalities, the Scn8amedJ mutation may also affect sensory systems.
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B. RudyP. Seeburg
- 1
Current address: Department of Genetics, Duke University Medical Center, Durham, NC 27710.
- 2
To whom correspondence should be addressed at Department of Human Genetics, Medical Science II, M4708, University of Michigan Medical School, Ann Arbor, MI 48109-0618. Telephone: (734) 763-1053. Fax: (734) 763-9691. E-mail:[email protected].