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- Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
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PDFGenome-wide studies
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Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
Authors
- Elisabeth M van Leeuwen Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Aniko Sabo Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA PubMed articlesGoogle scholar articles
- Joshua C Bis Department of Medicine, University of Washington, Seattle, USA PubMed articlesGoogle scholar articles
- Jennifer E Huffman Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK The Framingham Heart Study, NHLBI Cardiovascular Epidemiology and Human Genomics Branch, Framingham, USA PubMed articlesGoogle scholar articles
- Ani Manichaikul Center for Public Health Genomics, University of Virginia, Charlottesville, USA PubMed articlesGoogle scholar articles
- Albert V Smith Icelandic Heart Association, Kopavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
- Mary F Feitosa Department of Genetics, Washington University School of Medicine, St Louis, USA PubMed articlesGoogle scholar articles
- Serkalem Demissie Department of Biostatistics, Boston University School of Public Health, Boston, USA PubMed articlesGoogle scholar articles
- Peter K Joshi Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Qing Duan Department of Genetics, University of North Carolina, Chapel Hill, USA PubMed articlesGoogle scholar articles
- Jonathan Marten Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Jan B van Klinken Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Ida Surakka Human Genomics Unit, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland PubMed articlesGoogle scholar articles
- Ilja M Nolte Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Weihua Zhang Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK PubMed articlesGoogle scholar articles
- Hamdi Mbarek Department of Biological Psychology, VU University Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Ruifang Li-Gao Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Stella Trompet Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Niek Verweij Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Evangelos Evangelou Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece PubMed articlesGoogle scholar articles
- Leo-Pekka Lyytikäinen Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland PubMed articlesGoogle scholar articles
- Bamidele O Tayo Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, USA PubMed articlesGoogle scholar articles
- Joris Deelen Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Peter J van der Most Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Sander W van der Laan Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
- Dan E Arking McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA PubMed articlesGoogle scholar articles
- Alanna Morrison Human Genetics Center, The University of Texas School of Public Health, Houston, USA PubMed articlesGoogle scholar articles
- Abbas Dehghan Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Oscar H Franco Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Albert Hofman Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Fernando Rivadeneira Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Eric J Sijbrands Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Andre G Uitterlinden Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Josyf C Mychaleckyj Center for Public Health Genomics, University of Virginia, Charlottesville, USA PubMed articlesGoogle scholar articles
- Archie Campbell Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Lynne J Hocking Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK PubMed articlesGoogle scholar articles
- Sandosh Padmanabhan British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
- Jennifer A Brody Department of Medicine, University of Washington, Seattle, USA PubMed articlesGoogle scholar articles
- Kenneth M Rice Department of Biostatistics, University of Washington, Seattle, USA PubMed articlesGoogle scholar articles
- Charles C White Brigham and Women's Hospital, Boston, USA PubMed articlesGoogle scholar articles
- Tamara Harris Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, USA PubMed articlesGoogle scholar articles
- Aaron Isaacs Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Harry Campbell Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Leslie A Lange Department of Genetics, University of North Carolina, Chapel Hill, USA PubMed articlesGoogle scholar articles
- Igor Rudan Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Ivana Kolcic Faculty of Medicine, University of Split, Split, Croatia PubMed articlesGoogle scholar articles
- Pau Navarro Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Tatijana Zemunik Faculty of Medicine, University of Split, Split, Croatia PubMed articlesGoogle scholar articles
- Veikko Salomaa Department of Health, National Institute for Health and Welfare, Helsinki, Finland PubMed articlesGoogle scholar articles
- The LifeLines Cohort StudyGoogle scholar articles
- Angad S Kooner Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Jaspal S Kooner Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, UK Imperial College Healthcare NHS Trus, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Benjamin Lehne Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- William R Scott Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK PubMed articlesGoogle scholar articles
- Sian-Tsung Tan Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Eco J de Geus Department of Biological Psychology, VU University Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Yuri Milaneschi Department of Psychiatry, VU University Medical Center Amsterdam/GGZinGeest and EMGO+ Institute for Health and Care Research and Neuroscience Campus Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Brenda W J H Penninx Department of Psychiatry, VU University Medical Center Amsterdam/GGZinGeest and EMGO+ Institute for Health and Care Research and Neuroscience Campus Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Gonneke Willemsen Department of Biological Psychology, VU University Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Renée de Mutsert Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Ian Ford Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
- Ron T Gansevoort Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Marcelo P Segura-Lepe Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Olli T Raitakari Department of Clinical Physiology, Turku University Hospital, Turku, Finland Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
- Jorma S Viikari Division of Medicine, Turku University Hospital, Turku, Finland Department of Medicine, University of Turku, Turku, Finland PubMed articlesGoogle scholar articles
- Kjell Nikus Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere, Finland School of Medicine, University of Tampere, Tampere, Finland PubMed articlesGoogle scholar articles
- Terrence Forrester Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica PubMed articlesGoogle scholar articles
- Colin A McKenzie Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica PubMed articlesGoogle scholar articles
- Anton J M de Craen Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Hester M de Ruijter Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
- CHARGE Lipids Working GroupGoogle scholar articles
- Gerard Pasterkamp Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
- Harold Snieder Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Albertine J Oldehinkel Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- P Eline Slagboom Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Richard S Cooper Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, USA PubMed articlesGoogle scholar articles
- Mika Kähönen Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland PubMed articlesGoogle scholar articles
- Terho Lehtimäki Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland PubMed articlesGoogle scholar articles
- Paul Elliott Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Pim van der Harst Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- J Wouter Jukema Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Dennis O Mook-Kanamori Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands Epidemiology Section, Department of BESC, King Faisal Medical Hospital and Research Centre, Riyadh, Saudi Arabia PubMed articlesGoogle scholar articles
- Dorret I Boomsma Department of Biological Psychology, VU University Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- John C Chambers Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK Imperial College Healthcare NHS Trus, Imperial College London, London, UK PubMed articlesGoogle scholar articles
- Morris Swertz Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
- Samuli Ripatti Human Genomics Unit, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland Public Health, University of Helsinki, Helsinki, Finland Wellcome Trust Sanger Institute, UK PubMed articlesGoogle scholar articles
- Ko Willems van Dijk Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
- Veronique Vitart Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Ozren Polasek Faculty of Medicine, University of Split, Split, Croatia PubMed articlesGoogle scholar articles
- Caroline Hayward Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- James G Wilson Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA PubMed articlesGoogle scholar articles
- James F Wilson Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
- Vilmundur Gudnason Icelandic Heart Association, Kopavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
- Stephen S Rich Center for Public Health Genomics, University of Virginia, Charlottesville, USA PubMed articlesGoogle scholar articles
- Bruce M Psaty Department of Medicine, University of Washington, Seattle, USA Department of Epidemiology, University of Washington, Seattle, USA Department of Health Services, University of Washington, Seattle, USA Group Health Cooperative, Group Health Research Institute, Seattle, USA PubMed articlesGoogle scholar articles
- Ingrid B Borecki Department of Genetics, Washington University School of Medicine, St Louis, USA PubMed articlesGoogle scholar articles
- Eric Boerwinkle Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA Human Genetics Center, The University of Texas School of Public Health, Houston, USA PubMed articlesGoogle scholar articles
- Jerome I Rotter Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, USA Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, USA Departments of Pediatrics, Medicine, and Human Genetics, UCLA, Los Angeles, USA PubMed articlesGoogle scholar articles
- L Adrienne Cupples The Framingham Heart Study, NHLBI Cardiovascular Epidemiology and Human Genomics Branch, Framingham, USA Department of Genetics, Washington University School of Medicine, St Louis, USA PubMed articlesGoogle scholar articles
- Cornelia M van Duijn Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
- Correspondence to Professor Cornelia M van Duijn, Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Postbus 2040, Rotterdam 3000 CA, The Netherlands; c.vanduijn{at}erasmusmc.nl
Citation
van Leeuwen EM, Sabo A, Bis JC, et al
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
Journal of Medical Genetics 2016;53:441-449.
Publication history
- Received August 4, 2015
- Revised November 19, 2015
- Accepted November 23, 2015
- First published April 1, 2016.
Online issue publication
June 23, 2016
Article Versions
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