Functional analysis of MSH2 unclassified variants found in suspected Lynch syndrome patients reveals pathogenicity due to attenuated mismatch repair

Eva AL Wielders; Jan Hettinger; Rob Dekker; C Marleen Kets; Marjolijn J Ligtenberg; Arjen R Mensenkamp; Ans MW van den Ouweland; Judith Prins; Anja Wagner; Winand NM Dinjens; Hendrikus Jan Dubbink; Liselotte P van Hest; Fred Menko; Frans Hogervorst; Senno Verhoef; Hein te Riele

doi:10.1136/jmedgenet-2013-101987

Article info

Cancer genetics

Original article

Functional analysis of MSH2 unclassified variants found in suspected Lynch syndrome patients reveals pathogenicity due to attenuated mismatch repair

Authors

Eva AL Wielders Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands PubMed articles Google scholar articles
Jan Hettinger Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands Tumor Immunology Program, German Cancer Research Center (DKFZ), Immune Tolerance, Heidelberg, Germany PubMed articles Google scholar articles
Rob Dekker Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands RNA Biology and Applied Bioinformatics group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands PubMed articles Google scholar articles
C Marleen Kets Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands PubMed articles Google scholar articles
Marjolijn J Ligtenberg Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands PubMed articles Google scholar articles
Arjen R Mensenkamp Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands PubMed articles Google scholar articles
Ans MW van den Ouweland Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Judith Prins Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Anja Wagner Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Winand NM Dinjens Department of Pathology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Hendrikus Jan Dubbink Department of Pathology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Liselotte P van Hest Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Fred Menko Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Frans Hogervorst The Netherlands Cancer Institute, Family Cancer Clinic, Amsterdam, The Netherlands PubMed articles Google scholar articles
Senno Verhoef The Netherlands Cancer Institute, Family Cancer Clinic, Amsterdam, The Netherlands PubMed articles Google scholar articles
Hein te Riele Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands PubMed articles Google scholar articles

Correspondence to Professor Hein te Riele, Division of Biological Stress Response, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands; h.t.riele{at}nki.nl

View Full Text

Citation

Wielders EA, Hettinger J, Dekker R, et al

Functional analysis of MSH2 unclassified variants found in suspected Lynch syndrome patients reveals pathogenicity due to attenuated mismatch repair

Journal of Medical Genetics 2014;51:245-253.

Publication history

Received August 5, 2013
Revised November 21, 2013
Accepted December 23, 2013
First published February 5, 2014.

Online issue publication

April 27, 2016

Article Versions

Previous version (27 April 2016).
You are viewing the most recent version of this article.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password