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Copy-number variation
Original article
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus

Authors

  • Ling Oei Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Yi-Hsiang Hsu Institute for Aging Research, Hebrew SeniorLife, Boston, USA Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, USA Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA PubMed articlesGoogle scholar articles
  • Unnur Styrkarsdottir deCODE Genetics, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Bert H Eussen Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Annelies de Klein Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Marjolein J Peters Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Bjarni Halldorsson deCODE Genetics, Reykjavik, Iceland School of Science and Engineering, Reykjavik University, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Ching-Ti Liu Department of Biostatistics, Boston University School of Public Health, Boston, USA PubMed articlesGoogle scholar articles
  • Nerea Alonso Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Stephen K Kaptoge Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Gudmar Thorleifsson deCODE Genetics, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Göran Hallmans Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden PubMed articlesGoogle scholar articles
  • Lynne J Hocking Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK PubMed articlesGoogle scholar articles
  • Lise Bjerre Husted Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark PubMed articlesGoogle scholar articles
  • Karen A Jameson MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK PubMed articlesGoogle scholar articles
  • Marcin Kruk Department of Biochemistry, Radioimmunology & Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland PubMed articlesGoogle scholar articles
  • Joshua R Lewis School of Medicine and Pharmacology, University of Western Australia, Perth, Australia Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia PubMed articlesGoogle scholar articles
  • Millan S Patel Department of Medical Genetics, University of British Columbia, Vancouver, Canada PubMed articlesGoogle scholar articles
  • Serena Scollen Department of Medicine, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Olle Svensson Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden PubMed articlesGoogle scholar articles
  • Stella Trompet Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Natasja M van Schoor Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Kun Zhu School of Medicine and Pharmacology, University of Western Australia, Perth, Australia Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia PubMed articlesGoogle scholar articles
  • Brendan M Buckley Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland PubMed articlesGoogle scholar articles
  • Cyrus Cooper MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK PubMed articlesGoogle scholar articles
  • Ian Ford Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • David Goltzman Department of Medicine, McGill University, Montreal, Canada PubMed articlesGoogle scholar articles
  • Jesús González-Macías Department of Medicine, University of Cantabria, RETICEF, Santander, Spain Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain PubMed articlesGoogle scholar articles
  • Bente Lomholt Langdahl Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark PubMed articlesGoogle scholar articles
  • William D Leslie Department of Internal Medicine, University of Manitoba, Winnipeg, Canada PubMed articlesGoogle scholar articles
  • Paul Lips Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Roman S Lorenc Department of Biochemistry, Radioimmunology & Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland PubMed articlesGoogle scholar articles
  • José M Olmos Department of Medicine, University of Cantabria, RETICEF, Santander, Spain Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain PubMed articlesGoogle scholar articles
  • Ulrika Pettersson-Kymmer Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden Department of Pharmacology and Neuroscience, Umeå University, Umeå, Sweden PubMed articlesGoogle scholar articles
  • David M Reid Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK PubMed articlesGoogle scholar articles
  • José A Riancho Department of Medicine, University of Cantabria, RETICEF, Santander, Spain Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain PubMed articlesGoogle scholar articles
  • P Eline Slagboom Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Carmen Garcia-Ibarbia Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain PubMed articlesGoogle scholar articles
  • Thorvaldur Ingvarsson Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland Institution of Health Science, University Of Akureyri, Akureyri, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Hrefna Johannsdottir deCODE Genetics, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Robert Luben Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Carolina Medina-Gómez Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Pascal Arp Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Kannabiran Nandakumar Institute for Aging Research, Hebrew SeniorLife, Boston, USA Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA PubMed articlesGoogle scholar articles
  • Stefan Th Palsson deCODE Genetics, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Gunnar Sigurdsson Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • Joyce B J van Meurs Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Yanhua Zhou Department of Biostatistics, Boston University School of Public Health, Boston, USA PubMed articlesGoogle scholar articles
  • Albert Hofman Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • J Wouter Jukema Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Huibert A P Pols Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Richard L Prince School of Medicine and Pharmacology, University of Western Australia, Perth, Australia Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia PubMed articlesGoogle scholar articles
  • L Adrienne Cupples Department of Biostatistics, Boston University School of Public Health, Boston, USA Framingham Heart Study, Framingham, USA PubMed articlesGoogle scholar articles
  • Christian R Marshall The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada McLaughlin Centre, University of Toronto, Toronto, Canada PubMed articlesGoogle scholar articles
  • Dalila Pinto The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Daisuke Sato The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Stephen W Scherer The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada McLaughlin Centre, University of Toronto, Toronto, Canada Department of Molecular Genetics, University of Toronto, Toronto, Canada PubMed articlesGoogle scholar articles
  • Jonathan Reeve Medicine box 157, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Unnur Thorsteinsdottir deCODE Genetics, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • David Karasik Institute for Aging Research, Hebrew SeniorLife, Boston, USA PubMed articlesGoogle scholar articles
  • J Brent Richards Department of Medicine, McGill University, Montreal, Canada Department of Human Genetics, Lady Davis Institute, McGill University, Montréal, Canada Department of Epidemiology and Biostatistics, Lady Davis Institute, McGill University, Montréal, Canada Department of Twin Research and Genetic Epidemiology, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Kari Stefansson deCODE Genetics, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articlesGoogle scholar articles
  • André G Uitterlinden Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Stuart H Ralston Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • John P A Ioannidis Stanford Prevention Research Center, Stanford University, Stanford, USA PubMed articlesGoogle scholar articles
  • Douglas P Kiel Institute for Aging Research, Hebrew SeniorLife, Boston, USA Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA Framingham Heart Study, Framingham, USA PubMed articlesGoogle scholar articles
  • Fernando Rivadeneira Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Karol Estrada Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Karol Estrada, Department of Internal Medicine, Erasmus Medical Center, PO Box 2040 Ee5-79, Rotterdam 3000CA, The Netherlands; j.estradagil{at}erasmusmc.nl
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Citation

Oei L, Hsu Y, Styrkarsdottir U, et al
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus
Journal of Medical Genetics 2014;51:122-131.

Publication history

  • Received September 20, 2013
  • Revised November 9, 2013
  • Accepted November 20, 2013
  • First published December 16, 2013.
Online issue publication 
April 27, 2016

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