Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: a study based on 7352 families from the German Hereditary Breast and Ovarian Cancer Consortium

Christine Fischer; Karoline Kuchenbäcker; Christoph Engel; Silke Zachariae; Kerstin Rhiem; Alfons Meindl; Nils Rahner; Nicola Dikow; Hansjörg Plendl; Irmgard Debatin; Tiemo Grimm; Dorothea Gadzicki; Ricarda Flöttmann; Judit Horvath; Evelin Schröck; Friedrich Stock; Dieter Schäfer; Ira Schwaab; Christiana Kartsonaki; Nasim Mavaddat; Brigitte Schlegelberger; Antonis C Antoniou; Rita Schmutzler; on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer

doi:10.1136/jmedgenet-2012-101415

Article info

Cancer genetics

Original article

Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: a study based on 7352 families from the German Hereditary Breast and Ovarian Cancer Consortium

Authors

Christine Fischer Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Karoline Kuchenbäcker Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Christoph Engel Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Silke Zachariae Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Kerstin Rhiem Department of Gynaecology and Obstetrics, Center for Familiar Breast and Ovarian Cancer, University Hospital of Cologne, Köln, Germany PubMed articles Google scholar articles
Alfons Meindl Department of Obstetrics and Gynecology, Division of Tumor Genetics, Klinikum rechts der Isar der Technischen Universität Muenchen, Munich, Germany PubMed articles Google scholar articles
Nils Rahner Institute of Human Genetics, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany PubMed articles Google scholar articles
Nicola Dikow Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Hansjörg Plendl Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articles Google scholar articles
Irmgard Debatin Institute of Human Genetics, University of Ulm, Ulm, Germany PubMed articles Google scholar articles
Tiemo Grimm Institute of Human Genetics, Biozentrum University of Würzburg, Würzburg, Germany PubMed articles Google scholar articles
Dorothea Gadzicki Institute of Cell and Molecular Pathology, Medical School Hannover, Hannover, Germany PubMed articles Google scholar articles
Ricarda Flöttmann Institute of Medical Genetics and Human Genetics, Charite’-Universitätsmedizin Berlin, Berlin, Germany PubMed articles Google scholar articles
Judit Horvath Institute of Human Genetics, University of Münster, Münster, Germany PubMed articles Google scholar articles
Evelin Schröck Institute of Clinical Genetics, Medical School, Technical University of Dresden, Dresden, Germany PubMed articles Google scholar articles
Friedrich Stock Institute of Human Genetics, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Dieter Schäfer Institute of Human Genetics, University of Frankfurt/Main, Frankfurt/Main, Germany PubMed articles Google scholar articles
Ira Schwaab Praxis für Humangenetik, Wiesbaden, Germany PubMed articles Google scholar articles
Christiana Kartsonaki Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK Department of Statistics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Nasim Mavaddat Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Brigitte Schlegelberger Institute of Cell and Molecular Pathology, Medical School Hannover, Hannover, Germany PubMed articles Google scholar articles
Antonis C Antoniou Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Rita Schmutzler Department of Gynaecology and Obstetrics, Center for Familiar Breast and Ovarian Cancer, University Hospital of Cologne, Köln, Germany PubMed articles Google scholar articles
on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer
Google scholar articles

Correspondence to Dr Christine Fischer, Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany; cfischer{at}uni-hd.de

View Full Text

Citation

Fischer C, Kuchenbäcker K, Engel C, et al

Journal of Medical Genetics 2013;50:360-367.

Publication history

Received October 14, 2012
Revised February 6, 2013
Accepted February 21, 2013
First published April 6, 2013.

Online issue publication

January 30, 2017

Article Versions

Previous version (27 April 2016).
You are viewing the most recent version of this article.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password