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Replication of Restless Legs Syndrome Loci in Three European Populations
  1. David Kemlink
  1. Department of Neurology, Charles University Prague, First Faculty of Medicine, Czech Republic
    1. Olli Polo
    1. University of Turku Sleep Research Unit, Turku, Finland
      1. Birgitte Frauscher
      1. University Clinic Innsbruck, Department of Neurology, Innsbruck, Austria
        1. Viola Gschlieser
        1. University Clinic Innsbruck, Department of Neurology, Innsbruck, Austria
          1. Birgitte Högl
          1. University Clinic Innsbruck, Department of Neurology, Innsbruck, Austria
            1. Werner Poewe
            1. University Clinic Innsbruck, Department of Neurology, Innsbruck, Austria
              1. Pavel Vodicka
              1. Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
                1. Jana Vavrova
                1. Department of Neurology, Charles University Prague, First Faculty of Medicine, Czech Republic
                  1. Karel Sonka
                  1. Department of Neurology, Charles University Prague, First Faculty of Medicine, Czech Republic
                    1. Sona Nevsimalova
                    1. Department of Neurology, Charles University Prague, First Faculty of Medicine, Czech Republic
                      1. Barbara Schormair
                      1. Helmholtz Zentrum Munich, Institute of Human Genetics, Germany
                        1. Peter Lichtner
                        1. Helmholtz Zentrum Munich, Institute of Human Genetics, Germany
                          1. Kaisa Silander
                          1. Department of Molecular Medicine, National Public Health Institute, and FIMM, Finland
                            1. Lena Peltonen
                            1. Department of Molecular Medicine, National Public Health Institute, and FIMM, Finland
                              1. Christian Gieger
                              1. Institute of Epidemiology, Helmholtz Zentrum Munich, Germany
                                1. H-Erich Wichmann
                                1. Institute of Epidemiology, Helmholtz Zentrum Munich, Germany
                                  1. Alexander Zimprich
                                  1. Department of Neurology, Medical University of Vienna, Austria
                                    1. Darina Roeske
                                    1. Max-Planck-Institute of Psychiatry, Munich, Germany
                                      1. Bertram Müller-Myhsok
                                      1. Max-Planck-Institute of Psychiatry, Munich, Germany
                                        1. Thomas Meitinger
                                        1. Helmholtz Zentrum Munich, Institute of Human Genetics, Germany
                                          1. Juliane Winkelmann (winkelmann{at}lrz.tu-muenchen.de)
                                          1. Helmholtz Zentrum Munich, Institute of Human Genetics, Germany

                                            Abstract

                                            Background: Restless legs syndrome (RLS) is associated to common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q.

                                            Methods: Our study investigated these variants in 649 RLS patients and 1230 controls from Czech Republic (290 cases and 450 controls), Austria (269 cases and 611 controls) and Finland (90 cases and 169 controls). Ten SNPs within the three genomic regions were selected according to the results of previous genome-wide scans. Samples were genotyped using Sequenom platforms.

                                            Results: We replicated associations for all loci in the combined samples set (rs2300478 in MEIS1, P= 1.26 × 10-5, odds ratio (OR)= 1.47, rs3923809 in BTBD9, P= 4.11 × 10-5, OR= 1.58 and rs6494696 in MAP2K5/LBXCOR1, P= 0.04764, OR= 1.27). Analyzing only familial cases against all controls, all three loci were significantly associated. Using sporadic cases only, we would confirm the association only to BTBD9.

                                            Conclusion: Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering.

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