Polymorphisms of CLEC4M had been associated with predisposition for infection by the SAR-CoV virus. DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A VNTR polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR, or (2) it was a spurious association due to unrecognized population structure in the VNTR. We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging SNPs approach. 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. But we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different part of China. The results indicated that genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.
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