Article Text

other Versions

PDF
Evidence for the association of Y chromosome haplogroups with the susceptibility to spermatogenic failure from a Chinese Han population
  1. Yuan Yang (yuan70323{at}263.net)
  1. Department of Medical Genetics,West China Hospital,Sichuan university, China
    1. Mingyi Ma (luyimamingyi{at}163.com)
    1. Department of Medical Genetics,West China Hospital,Sichuan university, China
      1. Lei Li (lilei73{at}yahoo.com)
      1. Reproductive Medicine Central, West China Second Hospital, Sichuan University, China
        1. Wei Zhang (docmmm{at}163.com)
        1. Department of Medical Genetics,West China Hospital,Sichuan university, China
          1. Cuiying Xiao (cyxiao99{at}gmail.com)
          1. Department of Medical Genetics,West China Hospital,Sichuan university, China
            1. Shangwei Li (shangweili{at}263.net)
            1. Reproductive Medicine Central, West China Second Hospital, Sichuan University, China
              1. yongxing Ma (mayongxing{at}263.net)
              1. Department of Medical Genetics,West China Hospital,Sichuan university, China
                1. Dachang Tao (taodach{at}sohu.com)
                1. Department of Medical Genetics,West China Hospital,Sichuan university, China
                  1. Yunqiang Liu (liuyqyy{at}hotmail.com)
                  1. Department of Medical Genetics,West China Hospital,Sichuan university, China
                    1. Li Lin (linli64{at}263.net)
                    1. Department of Medical Genetics,West China Hospital,Sichuan university, China
                      1. Sizhong Zhang (szzhangvip{at}163.com)
                      1. Department of Medical Genetics,West China Hospital,Sichuan university, China

                        Abstract

                        Introduction: Y-chromosomes are genetically highly variable due to frequent structural rearrangements. The variations may create a genetic background for the susceptibility to Y related spermatogenic impairment, although few data have been accumulated about the possible correlation between the Y chromosome haplotype and the predisposition of males to the spermatogenic failure.

                        Materials and Methods: To investigate the possible association of Y chromosome background with spermatogenic failure, we compared the distribution of 18 Y chromosome haplogroups between 414 infertile men with azoo/oligozoosperma and 262 normozoospermic men with or without AZFc deletions in a Han population of Southwest China.

                        Results: A significant population difference in Y haplogroup distribution was observed between the groups of normozoospermia and azoo/oligozoosperma, and between the patient groups of oligozoospermia and azoospermia without AZFc deletions. Inter-population comparison of Y haplogroup frequencies showed that the distribution of haplogroups C, K*and O3* were significantly different between the groups.

                        Conclusion: The present study provides evidence for the association of Y chromosome background with impaired spermatogenesis, suggesting that Y variations play a role in the occurrence and even the severity of spermatogenic failure. Furthermore, not only AZFc deletions, but also other Y chromosome structural variations may be important for determining the susceptibility to spermatogenic failure. Our findings emphasize the necessity of more extensive study on the Y variations for better understanding the spermatogenesis and its pathology.

                        • Y chromosome
                        • haplogroups
                        • spermatogenic failure

                        Statistics from Altmetric.com

                        Request permissions

                        If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.