Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the Major Histocompatibility Complex (MHC) region, on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn’s disease (CD). Objective and Methods: To further investigate the genetic overlap between these two inflammatory conditions, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1,256 patients and 2,938 unrelated controls documented significant associations for loci mapping to chromosomes 1q24 (rs12035082, P = 0.009), 6p22 (rs6908425, P = 0.00015) and 21q22 (rs2836754, P = 0.0003). Of note, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type-2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for a number of genes that contribute to the pathogenesis of immune-mediated disorders.
- Crohn's disease
- genetic susceptibility
- type 2 diabetes
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