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Psoriasis is associated with pleiotropic susceptibility loci identified in Type II Diabetes and Crohn's disease
  1. Natalie Wolf
  1. King's College London, United Kingdom
    1. Maria Quaranta
    1. King's College London, United Kingdom
      1. Natalie Prescott
      1. King's College London, United Kingdom
        1. Michael Allen
        1. King's College London, United Kingdom
          1. Rhodri Smith
          1. University of Manchester, United Kingdom
            1. A David Burden
            1. Glasgow Western Infirmary, United Kingdom
              1. Jane Worthington
              1. University of Manchester, United Kingdom
                1. Christopher Griffiths
                1. University of Manchester, United Kingdom
                  1. Christopher Mathew
                  1. King's College London, United Kingdom
                    1. Jonathan Barker
                    1. King's College London, United Kingdom
                      1. Francesca Capon (francesca.capon{at}genetics.kcl.ac.uk)
                      1. King's College London, United Kingdom
                        1. Richard C Trembath (richard.trembath{at}genetics.kcl.ac.uk)
                        1. King's College, London, United Kingdom

                          Abstract

                          Background: Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage analyses have clearly mapped a primary disease susceptibility locus to the Major Histocompatibility Complex (MHC) region, on chromosome 6p21. More recently, whole-genome association studies have identified two non-MHC disease genes (IL12B and IL23R), both of which also confer susceptibility to Crohn’s disease (CD). Objective and Methods: To further investigate the genetic overlap between these two inflammatory conditions, we investigated 15 CD-associated loci in a psoriasis case-control dataset. Results: The analysis of 1,256 patients and 2,938 unrelated controls documented significant associations for loci mapping to chromosomes 1q24 (rs12035082, P = 0.009), 6p22 (rs6908425, P = 0.00015) and 21q22 (rs2836754, P = 0.0003). Of note, the marker showing the strongest phenotypic effect (rs6908425) maps to CDKAL1, a gene also associated with type-2 diabetes. Conclusions: These results substantiate emerging evidence for a pleiotropic role for a number of genes that contribute to the pathogenesis of immune-mediated disorders.

                          • CDKAL1
                          • Crohn's disease
                          • genetic susceptibility
                          • psoriasis
                          • type 2 diabetes

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