Insulin degrading enzyme (IDE) on chromosome 10q24 has been previously proposed as candidate gene for late-onset Alzheimer`s disease (AD) based on its amyloid β-protein degrading activity. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene among Finnish AD patients (n=370) and control subjects (n=454) revealed SNPs rs4646953 and rs4646955 to be associated with AD conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
- Alzheimer`s disease
- Insulin degrading enzyme (IDE)
- Risk gene
- Single nucleotide polymorphism (SNP)
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.