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Insulin degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population
  1. Saila Vepsäläinen (saila.vepsalainen{at}uku.fi)
  1. University of Kuopio, Finland
    1. Michele Parkinson
    1. MassGeneral Institute for Neurodegenerative Disease, United States
      1. Seppo Helisalmi
      1. University of Kuopio, Finland
        1. Arto Mannermaa
        1. University of Kuopio, Finland
          1. Hilkka Soininen
          1. University Hospital and University of Kuopio, Finland
            1. Rudolph Tanzi
            1. MassGeneral Institute for Neurodegenerative Disease, United States
              1. Lars Bertram
              1. MassGeneral Institute for Neurodegenerative Disease, United States
                1. Mikko Hiltunen (mikko.hiltunen{at}uku.fi)
                1. University of Kuopio, Finland

                  Abstract

                  Insulin degrading enzyme (IDE) on chromosome 10q24 has been previously proposed as candidate gene for late-onset Alzheimer`s disease (AD) based on its amyloid β-protein degrading activity. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene among Finnish AD patients (n=370) and control subjects (n=454) revealed SNPs rs4646953 and rs4646955 to be associated with AD conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.

                  • Alzheimer`s disease
                  • Insulin degrading enzyme (IDE)
                  • Risk gene
                  • Single nucleotide polymorphism (SNP)

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