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Attenuated aerobic exercise capacity in CD36 deficiency
  1. Hidekatsu Yanai (yanaih{at}jikei.ac.jp)
  1. Hokkaido University School of Medicine, Japan
    1. Ichiro Watanabe
    1. Hokkaido University School of Medicine, Japan
      1. Kojiro Ishii
      1. Hokkaido University Graduate School of Education, Japan
        1. Mie Morimoto
        1. Hokkaido University School of Medicine, Japan
          1. Hironobu Fujiwara
          1. Hokkaido University School of Medicine, Japan
            1. Shigeru Yoshida
            1. Hokkaido University School of Medicine, Japan
              1. Shu-Ping Hui
              1. Health Sciences University of Hokkaido, Japan
                1. Kazuhiko Matsuno
                1. Hokkaido University School of Medicine, Japan
                  1. Hitoshi Chiba
                  1. Hokkaido University School of Medicine, Japan

                    Abstract

                    Background: An important role of CD36 in muscle fatty-acid (FA) uptake has been demonstrated in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency.

                    Participants and methods: We investigated the ventilatory threshold (VT) as well as serum FA changes in normal (n = 22) and CD36 deficient subjects (n = 12) during pedaling on a cycle ergometer.

                    Results: In CD36 deficient individuals FA levels were not decreased at peak work rate while FA levels were decreased by about 50% in normal subjects. CD36 deficient subjects showed significantly lower VT than normal subjects. A significant correlation was observed between VT and % changes in FA at peak work rate.

                    Conclusion: Present study demonstrated a reduced FA utilization and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for human aerobic exercise capacity.

                    • CD36
                    • anaerobic threshold
                    • exercise
                    • fatty acid

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