In a recent paper on functional classification of BRCA1 alleles of unknown clinical significance we reported that variant M1628V presented markedly reduced activity in a transcriptional assay, which suggested that it represented a deleterious variant. During the course of additional experiments we noticed that our constructs included a deletion that was overlooked leading to a truncated protein. Therefore, we generated new constructs and repeated the transcription assays. Contrary to what was reported this variant displayed ~80% of the wild type activity suggesting that it corresponds to a neutral variant. We regret this error and apologize for any confusion or inconvenience it may have caused.
- breast cancer
- functional analysis
- unclassified variants
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