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Challenges in the phenotypic characterization of patients in genetic studies of coronary artery disease
  1. Albert K Luo (albert.luo{at}case.edu)
  1. Case Western, United States
    1. Brian K Jefferson (jefferb{at}ccf.org)
    1. Cleveland Clinic, United States
      1. Mario J Garcia (garciam{at}ccf.org)
      1. Cleveland Clinic, United States
        1. Geoffrey S Ginsburg (geoffrey.ginsburg{at}duke.edu)
        1. Duke, United States
          1. Eric J Topol (eric.topol{at}case.edu)
          1. Case Western, United States

            Abstract

            Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology that now allows genotyping of hundreds of thousands of single nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, we review the salient issues to facilitate research in this important field.

            • Atherosclerosis
            • Coronary Artery Disease
            • Genetics
            • Myocardial Infarction

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