Article Text

other Versions

Somatic mutations of the Epidermal Growth Factor Receptor and non-small cell lung cancer
  1. Xiaozhu Zhang (xiaozhu{at}
  1. Division of Biomedical Sciences, Johns Hopkins in Singapore, Singapore
    1. Alex Chang (alexchang{at}
    1. International medical centre, Johns Hopkins Singapore, Singapore


      Frequent overexpression of epidermal growth factor receptor (EGFR) in non-small cell lung cancers (NSCLC) makes EGFR as a new therapeutic target. Two specific EGFR tyrosine kinase inhibitors (TKIs), Gefitinib (ZD1839, Iressa) and Erlotibib (OSI-774, Tarceva) have been developed and approved by U.S. Food and Drug Administration (FDA) for second- and third-line treatment of advanced NSCLC. The following clinical trials have revealed significant viability in the response rate among different NSCLC patients, which leads to the discovery of somatic EGFR activating mutations. This brief review summarizes the discovery and functional consequences of the mutations, their clinicopathological features, and significant implication in NSCLC treatment and prognosis.

      • EGFR
      • non-small cell lung cancer
      • somatic mutation

      Statistics from

      Request permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.